Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study.
Life course body mass index and risk of knee osteoarthritis at the age of 53 years: evidence from the 1946 British birth cohort study.
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DOI：
10.1136/ard.2011.154021
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发表时间：
2012-05
影响因子：
27.4
通讯作者：
Kuh D
中科院分区：
文献类型：
--
作者：
Wills AK;Black S;Cooper R;Coppack RJ;Hardy R;Martin KR;Cooper C;Kuh D
作者研究了一生中的身体质量指数(BMI)与中年膝骨性关节炎(OA)风险的关系，测试了在特定时期长期暴露于高BMI或高BMI对膝骨性关节炎风险的影响最大。一项以人口为基础的英国出生队列中的3035名男性和女性在53岁时接受了膝骨性关节炎的临床检查。身高和体重被测量了10次，时间从2岁到53岁。分析按性别分层，并根据职业和活动水平进行调整。女性膝关节骨性关节炎的患病率高于男性(12.9%(n=194)vs7.4%(n=108))。在男性中，体重指数和晚期膝骨性关节炎之间的关联在20岁时就很明显(p=0.038)，并一直持续到53岁(OR值为1.38(95%可信区间为1.11~1.71))。在女性中，有证据表明15岁时有关联(p=0.003)；53岁时，体重指数每增加一次z分数，OR为1.89(95%可信区间为1.59比2.24)。女性从童年开始和男性从青春期开始的BMI变化也与膝盖骨关节炎呈正相关。一种结构化的建模方法揭示了BMI与膝骨性关节炎的联系方式，表明在整个成年期长期暴露于高BMI风险最高，一旦将成年BMI考虑在内，青春期就不会产生额外的风险。这项研究表明，膝骨性关节炎的风险是从成年期暴露在高BMI环境中累积而来的。
The authors examined how body mass index (BMI) across life is linked to the risk of midlife knee osteoarthritis (OA), testing whether prolonged exposure to high BMI or high BMI at a particular period has the greatest influence on the risk of knee OA. A population-based British birth cohort of 3035 men and women underwent clinical examination for knee OA at age 53 years.Heights and weights were measured 10 times from 2 to 53 years. Analyses were stratified by gender and adjusted for occupation and activity levels. The prevalence of knee OA was higher in women than in men (12.9% (n=194) vs 7.4% (n=108)). In men, the association between BMI and later knee OA was evident at 20 years (p=0.038) and remained until 53 years (OR per z-score 1.38 (95% CI 1.11 to 1.71)). In women, there was evidence for an association at 15 years (p=0.003); at 53 years, the OR was 1.89 (95% CI 1.59 to 2.24) per z-score increase in BMI. Changes in BMI from childhood in women and from adolescence in men were also positively associated with knee OA. A structured modelling approach to disentange the way in which BMI is linked to knee OA suggested that prolonged exposure to high BMI throughout adulthood carried the highest risk and that there was no additional risk conferred from adolescence once adult BMI had been accounted for. This study suggests that the risk of knee OA accumulates from exposure to a high BMI through adulthood.
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影响因子：
27.4
作者：
Manninen, P;Riihimaki, H;Suomalainen, O
通讯作者：
Suomalainen, O
影响因子：
7
作者：
Holliday, K. L.;McWilliams, D. F.;Doherty, M.
通讯作者：
Doherty, M.
影响因子：
2.1
作者：
Holmberg, S;Thelin, A;Thelin, N
通讯作者：
Thelin, N
影响因子：
6.3
作者：
Dawson, J;Juszczak, E;Fitzpatrick, R
通讯作者：
Fitzpatrick, R
DOI：
10.1093/gerona/60.2.224
发表时间：
2005-02-01
影响因子：
5.1
作者：
Kuh, D;Bassey, EJ;Wadsworth, MEJ
通讯作者：
Wadsworth, MEJ