Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China.
Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China.
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DOI：
10.1038/ncomms1432
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发表时间：
2011-08-09
影响因子：
16.6
通讯作者：
中科院分区：
文献类型：
--
作者：
通常在大空间尺度上观察到不同地点之间流感发病率的变化。目前尚不清楚这种变化是否发生在较小的空间尺度上，以及它是否是人口统计异质性的结果，还是人口结构和连通性方面更微妙的差异的结果。在这里，我们显示了中国各社区对甲型流感病毒的免疫力存在显着差异，而这不能用人口统计差异来解释。我们从中国广州附近随机选择的 5 个地点随机抽取家庭来回答问卷并提供血液样本，用于针对 5 种最近流行的流感病毒的血清学检测。我们发现，随着年龄的增长，可检测到的中和滴度的频率显着降低，在老年组中趋于平稳。不同地区在年龄、就业状况、疫苗接种史、家庭规模和住房条件方面存在显着差异。然而，调整后，可检测的中和滴度频率在不同位置之间仍然存在显着差异。这些结果表明，除了个人和家庭层面的风险因素之外，还有一些社区特征可以推动流感传播动态，并且这些因素的影响与毒株无关。
Variation in influenza incidence between locations is commonly observed on large spatial scales. It is unclear whether such variation occurs on smaller spatial scales and whether it is the result of heterogeneities in population demographics or more subtle differences in population structure and connectivity. Here we show significant differences in immunity to influenza A viruses among communities in China not explained by differences in population demographics. We randomly selected households from 5 randomly selected locations near Guangzhou, China to answer a questionnaire and provide a blood sample for serological testing against 5 recently circulating influenza viruses. We find a significant reduction in the frequency of detectable neutralization titers with increasing age, leveling off in older age groups. There are significant differences between locations in age, employment status, vaccination history, household size and housing conditions. However, after adjustment, significant variations in the frequency of detectable neutralization titers persists between locations. These results suggest there are characteristics of communities that drive influenza transmission dynamics apart from individual and household level risk factors, and that such factors have effects independent of strain.
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