Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer.
Regulatory T Cells Exhibit Distinct Features in Human Breast Cancer.
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DOI：
10.1016/j.immuni.2016.10.032
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发表时间：
2016-11-15
期刊：
影响因子：
32.4
通讯作者：
Rudensky, Alexander Y.
中科院分区：
文献类型：
--
作者：
Plitas, George;Konopacki, Catherine;Wu, Kenmin;Bos, Paula D.;Morrow, Monica;Putintseva, Ekaterina V.;Chudakov, Dmitriy M.;Rudensky, Alexander Y.
调节性T（Treg）细胞存在于淋巴器官和屏障组织中，在那里它们控制不同类型的炎症反应。Treg细胞也存在于人类癌症中，动物模型的研究表明它们有助于癌症的进展。然而，人肿瘤内Treg细胞和存在于相应正常组织中的Treg细胞的性质在很大程度上仍然未知。在这里，我们分析了未经治疗的人乳腺癌，正常乳腺和外周血中Treg细胞的特征。肿瘤驻留Treg细胞具有强效抑制性，其基因表达模式与正常乳腺组织相似，但与活化的外周血Treg细胞不同。然而，与正常组织驻留的Treg细胞相比，许多细胞因子和趋化因子受体基因，最显著的是CCR8，在肿瘤驻留的Treg细胞中上调。我们的研究表明，靶向CCR8以耗尽肿瘤驻留Treg细胞可能代表了治疗乳腺癌的有希望的免疫方法。
Regulatory T (Treg) cells reside in lymphoid organs and barrier tissues where they control different types of inflammatory responses. Treg cells are also found in human cancers, and studies in animal models suggest that they contribute to cancer progression. However, properties of human intratumoral Treg cells and those present in corresponding normal tissue remain largely unknown. Here, we analyzed features of Treg cells in untreated human breast carcinomas, normal mammary gland, and peripheral blood. Tumor-resident Treg cells were potently suppressive and their gene expression pattern resembled that of normal breast tissue, but not of activated peripheral blood Treg cells. Nevertheless, a number of cytokine and chemokine receptor genes, most notably CCR8, were upregulated in tumor-resident Treg cells in comparison to normal tissue resident ones. Our studies suggest that targeting CCR8 for the depletion of tumor-resident Treg cells may represent a promising immunotherapeutic approach for the treatment of breast cancer.
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影响因子：
7.2
作者：
Coussens, Lisa M.;Pollard, Jeffrey W.
通讯作者：
Pollard, Jeffrey W.
DOI：
10.1186/s13058-014-0432-8
发表时间：
2014-09-06
期刊：
Breast cancer research : BCR
影响因子：
--
作者：
Liu S;Foulkes WD;Leung S;Gao D;Lau S;Kos Z;Nielsen TO
通讯作者：
Nielsen TO
影响因子：
11.2
作者：
Faget, Julien;Biota, Cathy;Menetrier-Caux, Christine
通讯作者：
Menetrier-Caux, Christine
影响因子：
11.2
作者：
Gobert, Michael;Treilleux, Isabelle;Menetrier-Caux, Christine
通讯作者：
Menetrier-Caux, Christine
影响因子：
30.5
作者：
Burzyn D;Benoist C;Mathis D
通讯作者：
Mathis D