Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels.
Short-echo three-dimensional H-1 MR spectroscopic imaging of patients with glioma at 7 Tesla for characterization of differences in metabolite levels.
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DOI：
10.1002/jmri.24672
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发表时间：
2015-05
影响因子：
4.4
通讯作者：
Nelson, Sarah J.
中科院分区：
文献类型：
--
作者：
Li, Yan;Larson, Peder;Chen, Albert P.;Lupo, Janine M.;Ozhinsky, Eugene;Kelley, Douglas;Chang, Susan M.;Nelson, Sarah J.
本研究的目的是评估使用短回波时间、7T 3D H-1 磁共振波谱成像 (MRSI) 序列来评估神经胶质瘤患者病变代谢特征的可行性。对 29 名神经胶质瘤患者进行了研究。 MRSI 数据是使用 CHESS 水抑制、光谱选择性绝热反转恢复脉冲和自动规定的脂质抑制外体积抑制以及自旋回波切片选择 (TE=30ms) 获得的。应用交错回扫回波平面轨迹来缩短总采集时间（约 10 分钟）。估计肿瘤以及正常外观的白质和灰质（NAWM、GM）中的相对代谢物比率。与 NAWM 相比，所有肿瘤级别的 T2 病灶中谷氨酰胺、肌醇、甘氨酸和谷胱甘肽相对于总肌酸 (tCr) 的水平均显着升高 (p < 0.05)，而 N-乙酰天冬氨酸相对于 tCr 的水平显着降低 (p < 0.05)。在 2 级神经胶质瘤中，总含胆碱化合物相对于 tCr 的水平显着升高 (p = 0.0137)，而谷氨酸相对于 tCr 的水平显着降低 (p = 0.0012)。 MRSI 灵敏度的提高以及可使用 7T MR 扫描仪评估的代谢物数量的增加对于评估神经胶质瘤患者很有意义。这项研究成功地证明了应用短回波自旋回波 MRSI 序列来检测肿瘤区域与正常大脑区域的特征差异。
The purpose of this study was to evaluate the feasibility of using a short echo time, 3D H-1 magnetic resonance spectroscopic imaging (MRSI) sequence at 7T to assess the metabolic signature of lesions for patients with glioma. 29 patients with glioma were studied. MRSI data were obtained using CHESS water suppression, spectrally-selective adiabatic inversion-recovery pulses and automatically prescribed outer-volume-suppression for lipid suppression, and spin echo slice selection (TE=30ms). An interleaved flyback echo-planar trajectory was applied to shorten the total acquisition time (~10min). Relative metabolite ratios were estimated in tumor and in normal-appearing white and gray matter (NAWM, GM). Levels of glutamine, myo-inositol, glycine and glutathione relative to total creatine (tCr) were significantly increased in the T2 lesions for all tumor grades compared to those in the NAWM (p < 0.05), while N-acetyl aspartate to tCr were significantly decreased (p < 0.05). In grade 2 gliomas, level of total choline-containing-compounds to tCr was significantly increased (p = 0.0137), while glutamate to tCr was significantly reduced (p = 0.0012). The improved sensitivity of MRSI and the increased number of metabolites that can be evaluated using 7T MR scanners is of interest for evaluating patients with glioma. This study has successfully demonstrated the application of a short-echo spin-echo MRSI sequence to detect characteristic differences in regions of tumor versus normal appearing brain.
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