Current status of hand-foot-and-mouth disease.
Current status of hand-foot-and-mouth disease.
复制标题
手足口病的现状。
DOI：
10.1186/s12929-023-00908-4
复制
发表时间：
2023-02-24
影响因子：
11
通讯作者：
Duan, Guangcai
中科院分区：
文献类型：
--
作者：
Zhu, Peiyu;Ji, Wangquan;Li, Dong;Li, Zijie;Chen, Yu;Dai, Bowen;Han, Shujie;Chen, Shuaiyin;Jin, Yuefei;Duan, Guangcai
关键词：
手足口病是一种常见于5岁以下幼儿的病毒性疾病，其典型表现为口腔疱疹和手脚皮疹。这些症状通常在几天内自发消退，无并发症。在过去的二十年里，我们对手足口病的认识有了很大的提高，它受到了极大的关注。包括流行病学、动物和体外研究在内的各种研究表明，这种疾病可能与潜在的致命性神经系统并发症有关。这些发现揭示了临床、流行病学、病理学和病因学特征，这些特征与对疾病的最初理解截然不同。值得注意的是，手足口病与严重的心肺并发症有关，以及在随访期间可以观察到的严重神经系统后遗症。目前，没有针对手足口病的药物干预。一种已获国家食品药品监督管理总局（CFDA）批准的EV-A71灭活疫苗已被证明对EV-A71相关的手足口病提供高水平的保护。然而，多种病原体的同时传播和传染媒介分子流行病学的演变使得仅基于单一媒介的干预措施相对不足。肠道病毒具有高度传染性，并对神经系统有偏好，特别是在儿童人群中，这导致了持续的爆发。鉴于手足口病在世界各地的重大影响，本综述综合了手足口病病毒学、流行病学、发病机制、治疗、后遗症和疫苗开发的现有知识，以改善临床实践和公共卫生工作。
Hand-foot-and-mouth disease (HFMD) is a viral illness commonly seen in young children under 5 years of age, characterized by typical manifestations such as oral herpes and rashes on the hands and feet. These symptoms typically resolve spontaneously within a few days without complications. Over the past two decades, our understanding of HFMD has greatly improved and it has received significant attention. A variety of research studies, including epidemiological, animal, and in vitro studies, suggest that the disease may be associated with potentially fatal neurological complications. These findings reveal clinical, epidemiological, pathological, and etiological characteristics that are quite different from initial understandings of the illness. It is important to note that HFMD has been linked to severe cardiopulmonary complications, as well as severe neurological sequelae that can be observed during follow-up. At present, there is no specific pharmaceutical intervention for HFMD. An inactivated Enterovirus A71 (EV-A71) vaccine that has been approved by the China Food and Drug Administration (CFDA) has been shown to provide a high level of protection against EV-A71-related HFMD. However, the simultaneous circulation of multiple pathogens and the evolution of the molecular epidemiology of infectious agents make interventions based solely on a single agent comparatively inadequate. Enteroviruses are highly contagious and have a predilection for the nervous system, particularly in child populations, which contributes to the ongoing outbreak. Given the substantial impact of HFMD around the world, this Review synthesizes the current knowledge of the virology, epidemiology, pathogenesis, therapy, sequelae, and vaccine development of HFMD to improve clinical practices and public health efforts.
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影响因子：
11.8
作者：
Akhmadishina LV;Govorukhina MV;Kovalev EV;Nenadskaya SA;Ivanova OE;Lukashev AN
通讯作者：
Lukashev AN
影响因子：
2
作者：
Kim YJ;Kim TG
通讯作者：
Kim TG
影响因子：
33.9
作者：
Abedi, Glen R.;Watson, John T.;Gerber, Susan I.
通讯作者：
Gerber, Susan I.
影响因子：
1.5
作者：
Bujaki, Erika;Farkas, Agnes;Takacs, Maria
通讯作者：
Takacs, Maria
影响因子：
5.4
作者：
Brown, BA;Oberste, MS;Pallansch, MA
通讯作者：
Pallansch, MA