Optimization strategies for ACI: A step-chronicle review
Optimization strategies for ACI: A step-chronicle review
复制标题
ACI 的优化策略：逐步回顾
DOI：
10.1016/j.jot.2018.12.005
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发表时间：
2019
影响因子：
6.6
通讯作者：
H. Ouyang
中科院分区：
文献类型：
--
作者：
Yuchen Xiang;Varitsara Bunpetch;Wenyan Zhou;H. Ouyang
关节软骨在日常生活中承受着邻近关节的压力，压力不断累积，容易损伤，但一旦损伤，由于其代谢特性较低，自我修复能力有限。自体软骨细胞植入是一种三步修复关节病变的技术，其近期临床效果令人满意，但其长期效果仍存在争议。目前，改进的干细胞疗法和新型生物材料为自体软骨细胞移植提供了新的思路。因此，我们将综合这些优化策略，以他们的存在，在三步protocol.The翻译潜力的这些strategies.The translational potential之间寻求发现和放大的协同效应，这articleAutobacterium软骨细胞植入作为一种替代治疗关节软骨病变，以避免潜在的不利影响，应用microfracture。优化的ACI应提高修复关节软骨的成本效益，同时避免潜在的并发症，如骨赘。本文综合了ACI的优化策略，并提出了相应的应用途径，以最大限度地发挥其协同效应。这将是联合使用干细胞和纳米技术再生软骨的开创性试验。
Bearing compression from adjacent joints, the articular cartilage is cumulatively pressured in daily life, thus making it prone to injuries; however, once damaged, the self-healing capacity of articular cartilage is limited owing to its low metabolic property. Autologous chondrocyte implantation, a three-step repairing technique for articular lesions, has received satisfactory short-term clinical outcomes, whereas its long-term effect remains controversial. Currently, improved stem-cell therapies and novel biomaterials have shed new lights on autologous chondrocyte implantation. We would, therefore, synthesize these optimization strategies in order of their presences in the three-step protocol, seeking to find and amplify synergic effects between these strategies.The translational potential of this articleAutologous chondrocytes implantation serves as an alternative for the treatment of articular cartilage lesions to avoid potentially detrimental effects of applying microfracture. The optimized ACI should improve the cost-effectiveness of repairing articular cartilage while circumventing latent complications like osteophyte. This article synthesized optimization strategies for ACI and provided appropriate applying approaches to maximize their synergic effects. It will be a pioneering trial for combinedly using stem cells and nanotechnology to regenerate cartilage.
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影响因子：
14
作者：
Kim, Iris L.;Mauck, Robert L.;Burdick, Jason A.
通讯作者：
Burdick, Jason A.
影响因子：
20.3
作者：
Jianwei Wang;Xin Lu;V. Sakk;C. Klein;K. Rudolph
通讯作者：
Jianwei Wang;Xin Lu;V. Sakk;C. Klein;K. Rudolph
影响因子：
1.1
作者：
D. Schaefer;D. Wendt;M. Moretti;M. Jakob;G. Jay;M. Heberer;I. Martin
通讯作者：
D. Schaefer;D. Wendt;M. Moretti;M. Jakob;G. Jay;M. Heberer;I. Martin
DOI：
10.1016/j.diff.2016.02.005
发表时间：
2016-07
期刊：
Differentiation; research in biological diversity
影响因子：
--
作者：
Almalki SG;Agrawal DK
通讯作者：
Agrawal DK
影响因子：
64.5
作者：
Chan CKF;Gulati GS;Sinha R;Tompkins JV;Lopez M;Carter AC;Ransom RC;Reinisch A;Wearda T;Murphy M;Brewer RE;Koepke LS;Marecic O;Manjunath A;Seo EY;Leavitt T;Lu WJ;Nguyen A;Conley SD;Salhotra A;Ambrosi TH;Borrelli MR;Siebel T;Chan K;Schallmoser K;Seita J;Sahoo D;Goodnough H;Bishop J;Gardner M;Majeti R;Wan DC;Goodman S;Weissman IL;Chang HY;Longaker MT
通讯作者：
Longaker MT