Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis.
Defining disease progression in Chinese mainland people: Association between bone mineral density and knee osteoarthritis.
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DOI：
10.1016/j.jot.2020.07.006
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发表时间：
2021-01
影响因子：
6.6
通讯作者：
Tong P
中科院分区：
文献类型：
--
作者：
Fang L;Xia C;Xu H;Ge Q;Shi Z;Kong L;Zhang P;Xu R;Zou Z;Wang P;Jin H;Tong P
评价中国社区老年人膝骨关节炎（OA）发生过程中骨密度（BMD）的变化。此外，通过记录声速（SOS）来监测疾病进展，SOS是定量超声测量提供的BMD的一个参数。对中国大陆的4173名社区居民进行问卷调查和相关测量，包括人体测量学、放射学和定量超声（QUS）。使用QUS测量获得桡骨远端的SOS测量值。由两名经验丰富的放射技师使用X线片评价膝关节OA的Kelling-Lawrence（KL）分级。最后，进行一般线性模型分析以确定潜在关系。此外，应用受试者工作特征曲线下面积（ROC AUC）评估区分模型。OA组SOS评分明显低于对照组（P < 0.001）。然而，在调整年龄和体重指数（BMI）后，男性人群中未观察到显著差异（p = 0.841），而女性人群中膝关节OA参与者的SOS评分显著较低（p = 0.033）。SOS评分的转折点，从增加到减少的趋势，发生在KL 2级左右; SOS评分随着KL 0级到2级参与者的进展而逐渐增加，而SOS评分在KL 3级和4级参与者中显着下降。用于区分OA进展的模型的AUC为0.891。SOS评分与膝关节OA之间存在非线性和阶段特异性相关，在早期阶段呈正相关，但在晚期阶段呈负相关。早期膝关节OA患者SOS评分下降应提醒临床医生注意疾病进展的可能性。在本研究中，骨关节炎和骨密度之间的关系已建立SOS。结果表明，密切监测中国社区老年膝关节骨性关节炎患者的SOS可以通过一种简单易行的方法提醒疾病进展，并有助于早期转诊至骨科医生进行进一步检查和治疗。
To evaluate change in bone mineral density (BMD) during development of knee osteoarthritis (OA) in elderly Chinese community residents. Further, to monitor disease progression by recording speed of sound (SOS), one parameter of BMD provided by quantitative ultrasound measurement. A total of 4173 community residents of the Chinese mainland were organized to complete questionnaires and relevant measurements, including anthropometry, radiology and quantitative ultrasound (QUS). SOS measurements of the distal radius were acquired using QUS measurements. The Kellgren-Lawrence (KL) grade of knee OA was evaluated by two experienced radiographers using X-rays. Finally, a general linear models analysis was performed to determine potential relationships. Further, the area under the receiver operating characteristic curve (ROC AUC) was applied to assess the distinction model. The SOS score in the OA group was significantly lower than that in the control group (p < 0.001). However, after adjustment for age and body mass index (BMI), no significant difference was observed in the male population (p ＝ 0.841), while a significantly lower SOS score presented in knee OA participants in the female population (p ＝ 0.033). A turning point in SOS scores, from increasing to decreasing trends, occurred around KL grade 2; the SOS score gradually increased with progression in participants from KL grades 0 to 2, whereas the SOS score presented a significant decrease in participants with KL grades 3 and 4. The AUC for the model to distinguish OA progression was 0.891. There was a non-linear and stage-specific association between SOS score and knee OA, which presented a positive relationship in early stages, but a negative relationship in advanced stages. A decline of SOS score in knee OA patients in early stages should alert clinicians to the possibility of disease progression. In the present study, the relationship between OA and BMD had established by SOS. The results suggested that close monitoring of SOS in elderly Chinese communities residents with knee OA could alert disease progression involvement by an easily accessible method, and help early referral to orthopedist consultation for further examination and treatment.
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影响因子：
2.3
作者：
Deng ZH;Zeng C;Li YS;Yang T;Li H;Wei J;Lei GH
通讯作者：
Lei GH
影响因子：
13.3
作者：
Bergink, Arjan P.;Rivadeneira, Fernando;van Meurs, Joyce B. J.
通讯作者：
van Meurs, Joyce B. J.
影响因子：
4.1
作者：
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通讯作者：
Wluka, Anita
影响因子：
6.2
作者：
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通讯作者：
Fogelman, I
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2.9
作者：
Grocholewicz, Katarzyna;Janiszewska-Olszowska, Joanna;Lipski, Mariusz
通讯作者：
Lipski, Mariusz