Rhythmic Firing of Pedunculopontine Tegmental Nucleus Neurons in Monkeys during Eye Movement Task.
Rhythmic Firing of Pedunculopontine Tegmental Nucleus Neurons in Monkeys during Eye Movement Task.
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DOI：
10.1371/journal.pone.0128147
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Kobayashi Y
中科院分区：
文献类型：
--
作者：
Okada K;Kobayashi Y
脚桥被盖核（PPTN）被认为参与行为状态的控制。其投射到整个丘脑以及与基底神经节核团的相互连接表明，PPTN在控制包括清醒/睡眠和运动在内的各种节律性行为中具有潜在作用。最近，在接受左旋多巴治疗的帕金森病患者的PPTN中记录到了局部场电位的节律性活动，这表明节律性放电是功能性PPTN的一个特征，并且即使在清醒状态下也可能随着行为状况而改变。然而，尚不清楚单个PPTN神经元在各种行为状况下（包括执行条件性眼球运动行为、寻求奖励或休息期间）是否以及如何呈现节律性放电模式。我们之前在健康猴子进行视觉引导的扫视任务期间记录了PPTN神经元，报道了放电率与任务相关的变化，在本文中，我们重新分析了这些数据并重点关注它们的放电模式。一部分PPTN神经元表现出一种规律的放电模式，即峰电位间期的变异系数低于理论上随机和不规则峰电位序列的预期值。此外，一组PPTN神经元表现出明显的周期性单峰放电，这种放电随行为任务的情境而改变。这些神经元中的许多在高度活跃的条件下表现出周期性放电模式，要么是扫视任务期间的注视条件，要么是试次间隔期间的自由观看条件。我们推测，PPTN神经元节律性放电的这些与任务情境相关的变化可能调节猴子执行任务的注意力和警觉状态。
The pedunculopontine tegmental nucleus (PPTN) has been thought to be involved in the control of behavioral state. Projections to the entire thalamus and reciprocal connections with the basal ganglia nuclei suggest a potential role for the PPTN in the control of various rhythmic behaviors, including waking/sleeping and locomotion. Recently, rhythmic activity in the local field potentials was recorded from the PPTN of patients with Parkinson's disease who were treated with levodopa, suggesting that rhythmic firing is a feature of the functioning PPTN and might change with the behaving conditions even within waking. However, it remains unclear whether and how single PPTN neurons exhibit rhythmic firing patterns during various behaving conditions, including executing conditioned eye movement behaviors, seeking reward, or during resting. We previously recorded from PPTN neurons in healthy monkeys during visually guided saccade tasks and reported task-related changes in firing rate, and in this paper, we reanalyzed these data and focused on their firing patterns. A population of PPTN neurons demonstrated a regular firing pattern in that the coefficient of variation of interspike intervals was lower than what would be expected of theoretical random and irregular spike trains. Furthermore, a group of PPTN neurons exhibited a clear periodic single spike firing that changed with the context of the behavioral task. Many of these neurons exhibited a periodic firing pattern during highly active conditions, either the fixation condition during the saccade task or the free-viewing condition during the intertrial interval. We speculate that these task context-related changes in rhythmic firing of PPTN neurons might regulate the monkey's attentional and vigilance state to perform the task.
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影响因子：
3
作者：
CRIST, CF;YAMASAKI, DSG;WURTZ, RH
通讯作者：
WURTZ, RH
影响因子：
3.3
作者：
GARCIARILL, F;SKINNER, RD
通讯作者：
SKINNER, RD
影响因子：
3.7
作者：
Fraix V;Bastin J;David O;Goetz L;Ferraye M;Benabid AL;Chabardes S;Pollak P;Debû B
通讯作者：
Debû B
影响因子：
5.3
作者：
Boucetta, Soufiane;Cisse, Youssouf;Jones, Barbara E.
通讯作者：
Jones, Barbara E.
影响因子：
2.5
作者：
Kobayashi, Y;Inoue, Y;Aizawa, H
通讯作者：
Aizawa, H