Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
Pedunculopontine nucleus area oscillations during stance, stepping and freezing in Parkinson's disease.
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DOI：
10.1371/journal.pone.0083919
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Debû B
中科院分区：
文献类型：
--
作者：
Fraix V;Bastin J;David O;Goetz L;Ferraye M;Benabid AL;Chabardes S;Pollak P;Debû B
桥脚区（PPNa）包括桥脚核和楔形核，属于中脑运动区。关于该区域在姿势和步态控制中的振荡机制知之甚少。我们检查了7名接受双侧PPNa植入以使步态冻结（FOG）失能的帕金森病患者在行走（步态的替代物）和站立时PPNa和皮层振荡活动的调节。在手术后的几天里，我们记录了两种多巴胺能药物条件下（关闭和打开左旋多巴）坐下、站立和原地行走时的行为数据以及PPNa的局部场电位。我们的研究结果显示，在左旋多巴关闭时，所有受试者在分步试验中都有FOG，而在左旋多巴关闭时，分步有效（FOG的平均持续时间从试验持续时间的61.7±36.1%减少到7.3±10.1%）。在左旋多巴作用下，PPNa α (5-12 Hz)振荡活性增加，β (13-35 Hz)和γ (65-90 Hz)振荡活性降低。在安静的站立和坐着时，PPNa的活性不受调节。我们的研究结果证实了PPNa在步态调节中的作用，并表明，在帕金森病中，步态困难可能与低频和高频之间的不平衡有关。
The pedunculopontine area (PPNa) including the pedunculopontine and cuneiform nuclei, belongs to the mesencephalic locomotor region. Little is known about the oscillatory mechanisms underlying the function of this region in postural and gait control. We examined the modulations of the oscillatory activity of the PPNa and cortex during stepping, a surrogate of gait, and stance in seven Parkinson’s disease patients who received bilateral PPNa implantation for disabling freezing of gait (FOG). In the days following the surgery, we recorded behavioural data together with the local field potentials of the PPNa during sitting, standing and stepping-in-place, under two dopaminergic medication conditions (OFF and ON levodopa). Our results showed that OFF levodopa, all subjects had FOG during step-in-place trials, while ON levodopa, stepping was effective (mean duration of FOG decreasing from 61.7±36.1% to 7.3±10.1% of trial duration). ON levodopa, there was an increase in PPNa alpha (5–12 Hz) oscillatory activity and a decrease in beta (13–35 Hz) and gamma (65–90 Hz) bands activity. PPNa activity was not modulated during quiet standing and sitting. Our results confirm the role of the PPNa in the regulation of gait and suggest that, in Parkinson disease, gait difficulties could be related to an imbalance between low and higher frequencies.
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