Parallel organization of contralateral and ipsilateral prefrontal cortical projections in the rhesus monkey.
Parallel organization of contralateral and ipsilateral prefrontal cortical projections in the rhesus monkey.
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DOI：
10.1186/1471-2202-6-32
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发表时间：
2005-05-03
期刊：
影响因子：
2.4
通讯作者：
Suski JL
中科院分区：
文献类型：
--
作者：
Barbas H;Hilgetag CC;Saha S;Dermon CR;Suski JL
新皮质连合在大脑半球的功能整合中起着重要作用。我们调查是否连合预测在前额叶皮质组织根据相同或不同的规则，在同一半球内，通过定量比较密度，地形，和层状起源的对侧和同侧的预测，标记后，单侧注射逆行示踪剂在前额叶区。连合投射神经元占同侧不到三分之一。尽管如此，从两个半球的投影在地形和相对密度上有很强的相关性。我们研究了对侧投射的分布在多大程度上取决于：（a）投射区域与注射部位同位区域的地理接近程度;（B）基于其层的数量和神经元密度的相关区域的结构类型。虽然这两种措施是很好的预测，结构类型是一个相对较强的决定因素的相对分布和密度的预测。同侧投射神经元分布在浅层（II-III）和深层（V-VI），各区域的比例不同。相反，对侧投射神经元主要发现在浅层，但仍然表现出梯度，其分布在皮质层内，与皮质类型显着相关，但不与地理接近的同伦区。同侧和对侧前额叶投射的组织在地形和相对密度上是相似的，不同之处仅在于同侧投射的总体密度比对侧高，且同侧投射的层起源比对侧更广泛。两侧的投射与相连区域的结构架构高度相关，它们非凡的组织可能是由不同皮质类型的间断发育建立的。第三层对侧投射的优势可以追溯到胼胝体系统的晚期发育，其功能可能在个体发育晚期的疾病中受到损害。
The neocortical commissures have a fundamental role in functional integration across the cerebral hemispheres. We investigated whether commissural projections in prefrontal cortices are organized according to the same or different rules as those within the same hemisphere, by quantitatively comparing density, topography, and laminar origin of contralateral and ipsilateral projections, labeled after unilateral injection of retrograde tracers in prefrontal areas. Commissural projection neurons constituted less than one third of the ipsilateral. Nevertheless, projections from the two hemispheres were strongly correlated in topography and relative density. We investigated to what extent the distribution of contralateral projections depended on: (a) geographic proximity of projection areas to the area homotopic to the injection site; (b) the structural type of the linked areas, based on the number and neuronal density of their layers. Although both measures were good predictors, structural type was a comparatively stronger determinant of the relative distribution and density of projections. Ipsilateral projection neurons were distributed in the superficial (II-III) and deep (V-VI) layers, in proportions that varied across areas. In contrast, contralateral projection neurons were found mostly in the superficial layers, but still showed a gradient in their distribution within cortical layers that correlated significantly with cortical type, but not with geographic proximity to the homotopic area. The organization of ipsilateral and contralateral prefrontal projections is similar in topography and relative density, differing only by higher overall density and more widespread laminar origin of ipsilateral than contralateral projections. The projections on both sides are highly correlated with the structural architecture of the linked areas, and their remarkable organization is likely established by punctuated development of distinct cortical types. The preponderance of contralateral projections from layer III may be traced to the late development of the callosal system, whose function may be compromised in diseases that have their root late in ontogeny.
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影响因子：
6
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通讯作者：
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