Spinal interneurons of the lower urinary tract circuits.
Spinal interneurons of the lower urinary tract circuits.
复制标题
DOI：
10.1016/j.autneu.2021.102861
复制
发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Karnup S
中科院分区：
文献类型：
--
作者：
Karnup S
尿液的储存和排泄需要膀胱和尿道肌肉之间的协调活动。这种协调是由一个包含脊髓、中脑和前脑网络的复杂系统协调的。正常情况下，膀胱骶骨副交感神经传出和支配纹状体外尿道括约肌的躯体运动神经元的活动模式之间存在相互作用。在脊髓水平，这种相互作用是由位于腰骶段的兴奋性和抑制性中间神经元群介导的。在这篇综述中，我将提出一个概述，目前确定的脊髓中间神经元和电路相关的下尿路，并将讨论其建立或假设的作用，在排尿周期。此外，最近发现的辅助脊髓神经元合奏命名为腰椎协调中心将被描述。性二型性和下尿路的发育特征，这可能在设计治疗储尿和排尿功能障碍的患者中发挥重要作用也被考虑在内。脊髓损伤严重损害甚至消除排尿能力。治疗这种异常需要详细的知识支持神经机制，因此在正常和脊髓动物的各种实验将进行讨论。最后，将提出一个可能的脊柱内机制的组织外尿道括约肌（EUS）爆裂，这代表了一种形式的间歇性EUS松弛在大鼠和小鼠。
The storage and elimination of urine requires coordinated activity between muscles of the bladder and the urethra. This coordination is orchestrated by a complex system containing spinal, midbrain and forebrain networks. Normally there is a reciprocity between patterns of activity in urinary bladder sacral parasympathetic efferents and somatic motoneurons innervating the striatal external urethral sphincter muscle. At the spinal level this reciprocity is mediated by ensembles of excitatory and inhibitory interneurons located in the lumbar-sacral segments. In this review I will present an overview of currently identified spinal interneurons and circuits relevant to the lower urinary tract and will discuss their established or hypothetical roles in the cycle of micturition. In addition, a recently discovered auxiliary spinal neuronal ensemble named lumbar spinal coordinating center will be described. Sexual dimorphism and developmental features of the lower urinary tract which may play a significant role in designing treatments for patients with urine storage and voiding dysfunctions are also considered. Spinal cord injuries seriously damage or even eliminate the ability to urinate. Treatment of this abnormality requires detailed knowledge of supporting neural mechanisms, therefore various experiments in normal and spinalized animals will be discussed. Finally, a possible intraspinal mechanism will be proposed for organization of external urethral sphincter (EUS) bursting which represents a form of intermittent EUS relaxation in rats and mice.
登录
查看更多内容
影响因子：
2.3
作者：
Muramatsu, Ken;Niwa, Masatoshi;Sasaki, Sei-Ichi
通讯作者：
Sasaki, Sei-Ichi
影响因子：
2.5
作者：
Bui, Tuan V.;Grande, Giovanbattista;Rose, P. Ken
通讯作者：
Rose, P. Ken
影响因子：
2.5
作者：
Blok, BFM;van Maarseveen, JTPW;Holstege, G
通讯作者：
Holstege, G
影响因子：
82.9
作者：
Courtine, Gregoire;Song, Bingbing;Sofroniew, Michael V.
通讯作者：
Sofroniew, Michael V.
影响因子：
2.4
作者：
Nadelhaft I;Miranda-Sousa AJ;Vera PL
通讯作者：
Vera PL