Mindfulness interventions for offsetting health risk following early life stress: Promising directions.
Mindfulness interventions for offsetting health risk following early life stress: Promising directions.
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DOI：
10.1016/j.bbih.2021.100338
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发表时间：
2021-11
期刊：
影响因子：
--
通讯作者：
Lindsay EK
中科院分区：
文献类型：
--
作者：
Lindsay EK
早期生活压力（ELS），常见于童年虐待，社会经济劣势和种族歧视，被认为会产生促炎表型，增加成年后健康状况不佳的风险。需要系统性的改变来解决ELS的根本原因，但是相当数量的成年人已经由于ELS暴露而面临更大的健康风险。针对压力途径的干预措施有可能中断成年期从ELS到炎症性疾病风险的轨迹。基于正念的干预（MBIs），训练对当下体验的接受，已经显示出减少压力和改善各种压力敏感的健康结果的希望。虽然MBIs主要在更多的人群中进行，但有证据表明，它们可能对改善有ELS病史的人的心理健康和健康相关的生活质量特别有效。这些影响是否延伸到身体健康仍然未知。为了阐明这个问题，我回顾了MBIs影响高危样本中炎症标志物的证据，探讨了MBIs改善不同高危人群中与压力相关的健康结局的前景，并描述了MBIs的适应性，这些适应性可能会增加暴露于ELS的人群的可接受性和有效性。这项先前的工作为对照良好的随机对照试验奠定了基础，以评估MBIs是否会影响暴露于ELS的人群中的压力和炎症通路，并为注重传播MBIs以达到这些高危人群的务实和实施试验奠定了基础。总体而言，这里收集的证据显示MBIs抵消与ELS相关的身体健康风险的潜力。
Early life stress (ELS), common to childhood maltreatment, socioeconomic disadvantage, and racial discrimination, is thought to create a proinflammatory phenotype that increases risk for poor health in adulthood. Systemic change is needed to address the root causes of ELS, but a substantial number of adults are already at increased health risk by virtue of ELS exposure. Interventions that target stress pathways have the potential to interrupt the trajectory from ELS to inflammatory disease risk in adulthood. Mindfulness-based interventions (MBIs), which train acceptance toward present-moment experience, have shown promise for reducing stress and improving a variety of stress-sensitive health outcomes. Although MBIs have primarily been conducted in more advantaged populations, evidence suggests that they may be uniquely effective for improving mental health and health-related quality of life among those with a history of ELS. Whether these effects extend to physical health remains unknown. To shed light on this question, I review evidence that MBIs influence inflammatory markers in at-risk samples, explore the promise of MBIs for improving stress-related health outcomes in diverse at-risk populations, and describe adaptations to MBIs that may increase their acceptability and efficacy in populations exposed to ELS. This prior work sets the stage for well-controlled RCTs to evaluate whether MBIs influence stress and inflammatory pathways among those exposed to ELS and for pragmatic and implementation trials focused on disseminating MBIs to reach these at-risk populations. Overall, the evidence assembled here shows the potential of MBIs for offsetting physical health risk related to ELS.
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影响因子：
5.2
作者：
Black DS;Slavich GM
通讯作者：
Slavich GM
DOI：
10.1016/j.bbi.2020.07.017
发表时间：
2020-10
期刊：
Brain, behavior, and immunity
影响因子：
--
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影响因子：
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作者：
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作者：
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通讯作者：
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影响因子：
4.2
作者：
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通讯作者：
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