Exposure to mouse allergen in U.S. homes associated with asthma symptoms.
Exposure to mouse allergen in U.S. homes associated with asthma symptoms.
复制标题
DOI：
10.1289/ehp.11847
复制
发表时间：
2009-03
影响因子：
10.4
通讯作者：
Zeldin DC
中科院分区：
文献类型：
--
作者：
Salo PM;Jaramillo R;Cohn RD;London SJ;Zeldin DC
大多数研究居住小鼠过敏原暴露对哮喘的影响的研究都集中在市中心人群。我们在具有全国代表性的美国家庭样本中检查了小鼠过敏原水平升高是否与居住者的哮喘状况相关。这项研究的数据是作为全国住房铅和过敏原调查的一部分收集的。这项横断面研究调查了美国 75 个不同地点的 831 个住房单元，共有 2,456 人居住。该调查通过问卷调查和环境观察获得了人口统计、家庭特征和居住者健康状况等信息。我们使用多克隆免疫分析来评估从各个室内场所收集的真空灰尘中小鼠尿蛋白 (MUP) 的浓度。在接受调查的家庭中，82% 的家庭可检测到 MUP 水平，其中 35% 的家庭中 MUP 浓度超过 1.6 μg/g，这一水平与小鼠过敏原致敏率增加有关。当前哮喘（定义为在过去 12 个月内患有医生诊断的哮喘和哮喘症状）与 MUP 水平升高呈正相关。观察到的关联因特应性状态而改变；在过敏个体中，MUP 水平升高 (> 1.6 μg/g) 会增加出现哮喘症状的几率 [调整后 OR = 1.93； 95% 置信区间 (CI)，1.14–3.27]，但我们发现未报告过敏的人之间没有关联（调整后 OR = 0.69；95% CI，0.33–1.44）。在过敏性哮喘中，居住的小鼠过敏原暴露是哮喘发病的重要危险因素。
Most studies investigating the role of residential mouse allergen exposures in asthma have focused on inner-city populations. We examined whether elevated mouse allergen levels were associated with occupants’ asthma status in a nationally representative sample of U.S. households. Data for this study were collected as part of the National Survey of Lead and Allergens in Housing. This cross-sectional study surveyed 831 housing units inhabited by 2,456 individuals in 75 different locations throughout the United States. The survey obtained information on demographics, household characteristics, and occupants’ health status by questionnaire and environmental observations. We used a polyclonal immunoassay to assess concentrations of mouse urinary protein (MUP) in vacuumed dust collected from various indoor sites. Of the surveyed homes, 82% had detectable levels of MUP, and in 35% of the homes, MUP concentrations exceeded 1.6 μg/g, a level that has been associated with increased mouse allergen sensitization rates. Current asthma, defined as having doctor-diagnosed asthma and asthma symptoms in the preceding 12 months, was positively associated with increased MUP levels. The observed association was modified by atopic status; in allergic individuals, elevated MUP levels (> 1.6 μg/g) increased the odds of having asthma symptoms [adjusted OR = 1.93; 95% confidence interval (CI), 1.14–3.27], but we found no association in those who did not report allergies (adjusted OR = 0.69; 95% CI, 0.33–1.44). In allergic asthma, residential mouse allergen exposure is an important risk factor for asthma morbidity.
登录
查看更多内容
影响因子：
10.4
作者：
Crain, EF;Walter, M;Stout, JW
通讯作者：
Stout, JW
影响因子：
14.2
作者：
Phipatanakul, W;Eggleston, PA;Wood, RA
通讯作者：
Wood, RA
DOI：
10.1007/s11524-007-9205-3
发表时间：
2007-07-01
影响因子：
6.6
作者：
Simons, Elinor;Curtin-Brosnan, Jean;Eggleston, Peyton A.
通讯作者：
Eggleston, Peyton A.
DOI：
10.1038/sj.jea.7500244
发表时间：
2002-11-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Leech, JA;Nelson, WC;Raizenne, ME
通讯作者：
Raizenne, ME
影响因子：
14.2
作者：
Eggleston, PA;Rosenstreich, D;Malveaux, F
通讯作者：
Malveaux, F