Relationship between glycated haemoglobin levels and mean glucose levels over time.
Relationship between glycated haemoglobin levels and mean glucose levels over time.
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DOI：
10.1007/s00125-007-0803-0
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发表时间：
2007-11
期刊：
影响因子：
8.2
通讯作者：
Regan S
中科院分区：
文献类型：
--
作者：
Nathan DM;Turgeon H;Regan S
糖化血红蛋白(HbA1c)，用成人糖化血红蛋白的百分比表示，是慢性血糖症最广泛使用的指标。达到接近正常的HbA1c水平已被证明可以减少长期并发症，建议使用HbA1c检测来确定治疗是否足够并指导调整。然而，每日的治疗调整是由毛细血管血糖水平指导的(莫莫尔/L)。我们确定了一段时间内平均血糖水平的准确测量与HbA1c水平之间的关系，以及HbA1c是否可以用与自我监测结果相同的单位来表达。22名糖尿病患者和3名非糖尿病患者参与了这项纵向观察性研究。平均血糖水平由连续血糖监测(CGM)测量，每隔5分钟测量一次间质血糖水平，持续12周。每天进行4次毛细血管测量，以确认CGM的准确性。分别于基线和每4周测定一次HbA1c。8周和12周的HbA1c结果与之前8周和12周的CGM结果有很强的相关性(r = 为0.9)。曲线(指数)关系和线性回归以类似的高相关性捕捉到了这种关系，这允许将HbA1c值转换为计算的平均血糖水平。HbA1c与之前8-12周平均血糖的完整测量密切相关。为了报告和管理的目的，将HbA1c转换为平均血糖水平是可行的。
HbA1c, expressed as the percentage of adult haemoglobin that is glycated, is the most widely used measure of chronic glycaemia. Achieving near-normal HbA1c levels has been shown to reduce long-term complications and the HbA1c assay is recommended to determine whether treatment is adequate and to guide adjustments. However, daily adjustments of therapy are guided by capillary glucose levels (mmol/l). We determined the relationship between an accurate measure of mean glucose levels over time and the HbA1c level, and whether HbA1c can be expressed in the same units as self-monitoring results. Twenty-two participants with diabetes and three non-diabetic participants were included in this longitudinal observational study. Mean glucose levels were measured by continuous glucose monitoring (CGM), which measures interstitial glucose levels every 5 min, for 12 weeks. Capillary measurements were obtained four times per day to confirm the accuracy of CGM. HbA1c was measured at baseline and every 4 weeks. The HbA1c results at weeks 8 and 12 correlated strongly (r = 0.90) with the CGM results during the preceding 8 and 12 weeks. A curvilinear (exponential) relationship and a linear regression captured the relationship with similarly high correlations, which allowed transformation of HbA1c values to a calculated mean glucose level. HbA1c correlates closely with a complete measure of average glycaemia over the preceding 8–12 weeks. The translation of HbA1c to an average glucose level for reporting and management purposes is feasible.
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影响因子：
16.2
作者：
Clarke, WL;Anderson, S;Kovatchev, B
通讯作者：
Kovatchev, B
影响因子：
158.5
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通讯作者：
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影响因子：
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作者：
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Chalew, SA