The relationship between subjective reports of fatigue and executive control in multiple sclerosis.
The relationship between subjective reports of fatigue and executive control in multiple sclerosis.
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DOI：
10.1016/j.jns.2009.02.360
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发表时间：
2009-06-15
影响因子：
4.4
通讯作者：
Foley F
中科院分区：
文献类型：
--
作者：
Holtzer R;Foley F
以前的研究未能表明疲劳和认知表现之间的关系。我们使用了一个基于理论的延迟项目识别（Delayed Item Recognition，EAI）范式来检验这一假设，即主观报告的疲劳和执行控制过程相关的MS。参与者是20名确诊MS复发缓解过程的患者和20名年龄、性别、教育和智商相匹配的对照组。在三种条件下，执行性要求被操纵：单独、部分干扰（PI）和完全干扰（CI）。使用疲劳严重程度量表（FSS）评估疲劳。结果如下：ANOVA重复测量分析表明，在三种任务条件下，MS和增加的执行要求的函数，ESTA性能是较慢的，不太准确。单独的线性回归分析显示，疲劳是相关的快速反应时间和准确性的性能，只有在CI条件下，执行需求最大化，只有在MS组。本研究提供了第一个行为证据，疲劳和执行控制是唯一相关的MS。
Previous studies failed to show a relationship between fatigue and cognitive performance. We used a theory-based Delayed Item Recognition (DIR) paradigm to examine the hypothesis that subjective reports of fatigue and executive control processes were related in MS. Participants were 20 individuals diagnosed with definite diagnosis of MS with Relapsing-Remitting course and 20 controls case matched for age, sex, education and IQ. The DIR paradigm manipulated executive demands in three conditions: Alone, Partial Interference (PI), and Complete Interference (CI). Fatigue was assessed using the Fatigue Severity Scale (FSS). Results: ANOVA Repeated measures analyses showed that DIR performance was slower and less accurate as a function of MS and increased executive demands across the three task conditions. Separate linear regressions revealed that fatigue was related to DIR reaction time and accuracy performance only in the CI condition where executive demands are maximized, and only in the MS group. The present study provided first behavioral evidence that fatigue and executive control are uniquely related in MS.
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