Healthy aging and the blood-brain barrier.
Healthy aging and the blood-brain barrier.
复制标题
健康老化与血脑屏障。
DOI：
10.1038/s43587-021-00043-5
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Erickson MA
中科院分区：
文献类型：
--
作者：
Banks WA;Reed MJ;Logsdon AF;Rhea EM;Erickson MA
血脑屏障（BBB）保护中枢神经系统（CNS）免受不受管制的暴露于血液及其内容物。血脑屏障还控制许多物质的血-脑和脑-血渗透，导致中枢神经系统的营养，其稳态调节和中枢神经系统与外周组织之间的沟通。形成血脑屏障的细胞与大脑和周围的细胞交流。这种高度调控的界面随着健康的衰老而变化。在这里，我们回顾这些变化，从形态和破坏开始。转运蛋白的改变包括淀粉样肽、葡萄糖和药物。脑流体动力学、周细胞健康、基底膜和糖萼组成都随着健康的衰老而改变。携带ApoE4等位基因会导致血脑屏障中大多数与年龄相关的变化加速。我们讨论了随着健康衰老而发生的血脑屏障改变如何反映了对生命后生育阶段的适应，并可能影响对年龄相关疾病的易感性。
The blood-brain barrier (BBB) protects the central nervous system (CNS) from unregulated exposure to the blood and its contents. The BBB also controls the blood-to-brain and brain-to-blood permeation of many substances, resulting in nourishment of the CNS, its homeostatic regulation and communication between the CNS and peripheral tissues. The cells forming the BBB communicate with cells of the brain and in the periphery. This highly regulated interface changes with healthy aging. Here, we review those changes, starting with morphology and disruption. Transporter changes include those for amyloid beta peptide, glucose and drugs. Brain fluid dynamics, pericyte health and basement membrane and glycocalyx compositions are all altered with healthy aging. Carrying the ApoE4 allele leads to an acceleration of most of the BBB’s age-related changes. We discuss how alterations in the BBB that occur with healthy aging reflect adaptation to the postreproductive phase of life and may affect vulnerability to age-associated diseases.
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