Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging.
Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging.
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DOI：
10.2463/mrms.mp.2018-0053
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发表时间：
2019-04-10
期刊：
影响因子：
--
通讯作者：
Taoka T
中科院分区：
文献类型：
--
作者：
Naganawa S;Nakane T;Kawai H;Taoka T
有报道称，即使在健康人的脑脊液(CSF)中，静脉注射含Gd的造影剂(IV-GBCA)也会渗入脑脊液。本研究的目的是评估IV-GBCA后延迟显影患者皮质静脉的GBCA渗漏情况。回溯性研究分为两部分。在第一部分中，我们回顾了6名疑似内淋巴积水(EH)的患者，他们接受了单剂静脉注射GBCA(37-58岁)。分别于造影剂注射前、静脉注射GBCA后5min和4h获得三维真实的反转恢复图像。若5分钟时皮质静脉周围有强化，则皮质静脉渗漏至脑脊液为阳性，在静脉注射GBCA后4小时进一步扩散至脑脊液。在这项研究的第二部分，我们回顾了21例疑似EH患者(17-69岁)。仅在IV-GBCA后4h获得图像。计数皮质静脉GBCA渗漏阳性的脑片数目(NOS)。用Spearman等级相关系数评价一氧化氮合酶与年龄、性别、高血压程度的相关性。在研究的第一部分，所有患者皮质静脉的GBCA渗漏均为阳性。在研究的第二部分，所有年龄较大的患者(37岁以上)都可以看到皮质静脉的GBCA渗漏，但在5名较年轻的患者(37岁以下)中没有。神经型一氧化氮合酶仅与年龄显著相关(r=0.755，P<0.01)，而与性别、高血压程度无关。IV-GBCA从皮质静脉渗漏到周围的脑脊液。皮质静脉的渗漏与年龄显著相关，但与性别或高血压程度无关。
It has been reported that intravenously administered gadolinium-based contrast agents (IV-GBCAs) leak into the cerebrospinal fluid (CSF) even in healthy subjects. The purpose of this study was to evaluate GBCA leakage from the cortical veins in patients with delayed imaging after IV-GBCA. There are two parts of retrospective study. In the first part, we reviewed six patients with suspected endolymphatic hydrops (EH) who received a single dose of IV-GBCA (37–58 years old). The 3D-real inversion recovery images were obtained prior to the contrast administration as well as 5 min and 4 h after IV-GBCA. Leakage from the cortical veins to the CSF was graded as positive if enhancement around the cortical veins at 5 min was observed and had further spread into the CSF at 4 h after IV-GBCA. In the second part of this study, we reviewed 21 patients with suspected EH (17–69 years old). Images were obtained only at 4 h after IV-GBCA. The number of slices (NOS) with a positive GBCA leakage from the cortical veins was counted. The correlation of the NOS with age, gender, and degree of EH was evaluated by Spearman’s rank correlation coefficient. In the first part of the study, the GBCA leakage from the cortical veins was positive in all patients. In the second part of the study, the GBCA leakage from the cortical veins was seen in all older patients (above 37 years old), but not in the five younger patients (younger than 37 years old). The NOS correlated significantly only with age (r = 0.755, P < 0.01), but not with gender or degree of EH. IV-GBCA leaks from the cortical veins into the surrounding CSF. The leakiness of the cortical veins significantly correlated with age, but not with gender or degree of EH.
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DOI：
10.2463/mrms.ci.2016-0114
发表时间：
2017-04-10
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Naganawa S;Nakane T;Kawai H;Taoka T
通讯作者：
Taoka T
DOI：
10.2463/mrms.bc.2017-0158
发表时间：
2019-01-10
期刊：
Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine
影响因子：
--
作者：
Naganawa S;Kawai H;Taoka T;Sone M
通讯作者：
Sone M
影响因子：
3
作者：
Naganawa, Shinji;Kawai, Hisashi;Nakashima, Tsutomu
通讯作者：
Nakashima, Tsutomu
影响因子：
3.3
作者：
Lee, Hedok;Mortensen, Kristian;Benveniste, Helene
通讯作者：
Benveniste, Helene
影响因子：
4.4
作者：
Jessen NA;Munk AS;Lundgaard I;Nedergaard M
通讯作者：
Nedergaard M