Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery.
Crucial nuances in understanding (mis)associations between the neonatal microbiome and Cesarean delivery.
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DOI：
10.1016/j.molmed.2022.07.005
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发表时间：
2022-10
影响因子：
13.6
通讯作者：
Aagaard, Kjersti M.
中科院分区：
文献类型：
--
作者：
Sassin, Alexa M.;Johnson, Grace J.;Goulding, Alison N.;Aagaard, Kjersti M.
近几十年来，随着剖腹产率和常见的非传染性疾病（NCD），如肥胖，代谢性疾病和特应性/哮喘的同时增加，研究人员试图找出因果关系。一系列研究导致了一种假设，即剖腹产破坏了阴道微生物在新生儿微生物组中定植的假定正常过程，从而在以后的生活中产生NCD。然而，在分娩时中断的微生物群转移与通过剖腹产出生的婴儿的急性和/或慢性疾病之间的直接联系尚未建立因果关系。来自母体阴道或粪便来源的微生物群接种已被初步评估为旨在补偿剖腹产新生儿缺乏（或有限）暴露的干预措施。然而，迄今为止，临床试验尚未显示出新生儿“阴道播种”实践的明确健康益处。在完全确定这些微生物群改变的长期影响之前，最重要的是在怀孕和哺乳期间对临床上可改变的母体，营养或环境暴露对功能性微生物群的影响进行平行的有意义和机械性的询问，以确定它们在缓解儿童和成人NCD中的作用。
As rates of Cesarean delivery and common non-communicable disorders (NCDs) such as obesity, metabolic disease, and atopy/asthma have concomitantly increased in recent decades, investigators have attempted to discern a causal link. One line of research has led to a hypothesis that Cesarean birth disrupts the presumed normal process of colonization of the neonatal microbiome with vaginal microbes, yielding NCDs later-in-life. However, a direct link between a disrupted microbiota transfer at time of delivery and acute and/or chronic illness in infants born via Cesarean has not been causally established. Microbiota seeding from maternal vaginal or stool sources has been preliminarily evaluated as an intervention designed to compensate for the lack of (or limited) exposure to among Cesarean delivered neonates. However, to date, clinical trials have yet to show a clear health benefit with neonatal “vaginal seeding” practices. Until the long-term effects of these microbiome alterations can be fully determined, it is paramount to conduct parallel meaningful and mechanistic-minded interrogations of the impact of clinically modifiable maternal, nutritional, or environmental exposures on the functional microbiome over the duration of pregnancy and lactation to determine their role in the mitigation of childhood and adult NCDs.
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DOI：
10.1111/j.1365-2222.2012.04021.x
发表时间：
2012-09
期刊：
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
影响因子：
--
作者：
Almqvist C;Cnattingius S;Lichtenstein P;Lundholm C
通讯作者：
Lundholm C
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
14.6
作者：
Azad, Meghan B.;Konya, Theodore;Kozyrskyj, Anita L.
通讯作者：
Kozyrskyj, Anita L.
影响因子：
17.1
作者：
Aagaard K;Ma J;Antony KM;Ganu R;Petrosino J;Versalovic J
通讯作者：
Versalovic J
影响因子：
12.3
作者：
Chu DM;Antony KM;Ma J;Prince AL;Showalter L;Moller M;Aagaard KM
通讯作者：
Aagaard KM