A cross-sectional evaluation of the first cohort of young adults conceived by in vitro fertilization in the United States.

A cross-sectional evaluation of the first cohort of young adults conceived by in vitro fertilization in the United States.
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DOI:
10.1016/j.fertnstert.2009.12.023
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发表时间:
2010-11
影响因子:
6.7
通讯作者:
Oehninger S
Oehninger S
中科院分区:
医学2区
文献类型:
--
作者:
Beydoun HA;Sicignano N;Beydoun MA;Matson DO;Bocca S;Stadtmauer L;Oehninger S

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评估美国IVF受孕的最老一代年轻人的生活质量和慢性疾病发展的易感性。三级,单一诊所。1981年至1990年间通过标准试管婴儿受孕的年轻成年人。自填问卷。身体、心理和行为健康指标。在560名符合条件的年轻人中,有173人(31%)完成了问卷调查。平均年龄为21.2岁(范围18-26岁),男女性别比为3:4。通过配子捐赠受孕的数量有限,但没有通过卵母细胞/胚胎显微操作受孕的。超重和肥胖的患病率分别为35%和10%。超过65%的人曾被诊断患有慢性疾病;大多数诊断是精神病、眼科、呼吸系统和心脏代谢疾病。近40%的受访者是终身吸烟者,62%的受访者报告在前一年酗酒,超过90%的受访者在前一个月进行了身体活动。在选定的健康指标方面,调查参与者大多与1999-2004年全国健康和营养检查调查的子样本具有可比性。通过试管婴儿受孕的年轻人似乎是健康和适应良好的,尽管心理健康问题的优势需要进一步调查。
To assess the quality-of-life and susceptibility for chronic disease development of the oldest generation of young adults conceived by IVF in the U.S. Cross-sectional. Tertiary, single clinic. young adults conceived by standard IVF between 1981 and 1990. Self-administered questionnaire. indicators of physical, psychological and behavioral health. 173 (31%) of 560 eligible young adults completed the questionnaire. Mean age was 21.2 years (range 18–26) and male-to-female sex ratio was 3:4. A limited number was conceived through gamete donation but none through oocyte/embryo micromanipulation. Prevalence rates of overweight and obesity were 35% and 10%, respectively. Over 65% were ever diagnosed with a chronic condition; most diagnoses were psychiatric, ocular, respiratory and cardiometabolic in nature. Nearly 40% of respondents were lifetime smokers, 62% reported binge drinking in the previous year and over 90% were physically active in the previous month. Survey participants were mostly comparable to a sub-sample of the 1999–2004 National Health and Nutrition Examination Survey on selected health indicators. Young adults conceived by IVF appear to be healthy and well-adjusted, although the preponderance of psychological health problems requires further investigation.
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