Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.
Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.
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DOI：
10.1515/cclm-2012-0518
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发表时间：
2013-03-01
影响因子：
6.8
通讯作者：
Zeisel SH
中科院分区：
文献类型：
--
作者：
Zeisel SH
能量代谢、胰岛素抵抗和肥胖涉及多种已确定的机制，但迄今为止未知的代谢因素也会影响这些过程。动物模型研究表明胆碱/1-碳代谢与能量稳态之间存在重要联系。喂食缺乏胆碱饮食的啮齿动物会变得代谢亢进。胆碱代谢的几种不同基因之一缺失的小鼠具有的表型包括代谢率增加、体脂/瘦肉质量比降低、胰岛素敏感性增加、线粒体产生的 ATP 减少或高脂肪饮食体重增加减少。此外，农民已经认识到，在牛和猪饲料中添加胆碱代谢物（甜菜碱）可以降低体脂/瘦肉质量比。人类的胆碱膳食摄入量变化超过三倍，并且存在遗传变异，改变了个体对这种营养素的需求。尽管一些人类流行病学研究表明胆碱/1-碳代谢与能量代谢之间存在联系，但还没有专门针对人类进行的对照研究来检验这种关系。
There are multiple identified mechanisms involved in energy metabolism, insulin resistance and adiposity, but there are here-to-fore unsuspected metabolic factors that also influence these processes. Studies in animal models suggest important links between choline/1-carbon metabolism and energy homeostasis. Rodents fed choline deficient diets become hypermetabolic. Mice with deletions in one of several different genes of choline metabolism have phenotypes that include increased metabolic rate, decreased body fat/lean mass ratio, increased insulin sensitivity, decreased ATP production by mitochondria, or decreased weight gain on a high fat diet. In addition, farmers have recognized that the addition of a metabolite of choline (betaine) to cattle and swine feed reduces body fat/lean mass ratio. Choline dietary intake in humans varies over a >three-fold range, and genetic variation exists that modifies individual requirements for this nutrient. Although there are some epidemiologic studies in humans suggesting a link between choline/1-carbon metabolism and energy metabolism, there have been no controlled studies in humans that were specifically designed to examine this relationship.
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影响因子：
4.8
作者：
da Costa, Kerry-Ann;Kozyreva, Olga G.;Zeisel, Steven H.
通讯作者：
Zeisel, Steven H.
影响因子：
7.1
作者：
Elshorbagy, Amany K.;Nurk, Eha;Refsum, Helga
通讯作者：
Refsum, Helga
影响因子：
5.4
作者：
Bidulescu A;Chambless LE;Siega-Riz AM;Zeisel SH;Heiss G
通讯作者：
Heiss G
影响因子：
3.2
作者：
Esteve-Garcia, E;Mack, S
通讯作者：
Mack, S
影响因子：
2.1
作者：
Bidulescu, Aurelian;Chambless, Lloyd E;Heiss, Gerardo
通讯作者：
Heiss, Gerardo