Effect of coffee consumption on the risk of gastric cancer: a systematic review and meta-analysis of prospective cohort studies.
Effect of coffee consumption on the risk of gastric cancer: a systematic review and meta-analysis of prospective cohort studies.
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DOI：
10.1371/journal.pone.0128501
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发表时间：
2015
期刊：
影响因子：
3.7
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Liu H;Hua Y;Zheng X;Shen Z;Luo H;Tao X;Wang Z
关于咖啡消费与胃癌之间关系的观察性流行病学研究结果不一致且不确定。为了评估咖啡消费与胃癌风险之间的关系，我们总结了前瞻性队列研究的证据。通过计算机检索（PubMed、EmBase和科克伦图书馆）和截至2014年12月的参考文献综述检索相关研究。采用Newcastle-Ottawa质量评价量表评价纳入研究的质量。我们使用荟萃分析方法来估计经常喝咖啡的人与很少喝咖啡的人的总体风险比（HR）和95%置信区间（CI）。进行敏感性分析和亚组分析，以评估我们的结果的可靠性。进行了剂量反应分析，以评估基于咖啡消费水平的胃癌风险。本荟萃分析纳入了9项前瞻性队列研究，涉及1，250，825名参与者和3027例胃癌病例。研究特定的经常与很少喝咖啡类别的胃癌合并HR为1.05（95% CI，0.88 - 1.25），研究间具有显著异质性（I2 = 74.0%，P = 0.000）。敏感性分析后，删除了3项研究;但相关性仍然不显著（HR，0.99; 95% CI，0.91 - 1.08）。按解剖位置进行的亚组分析显示，咖啡消费与贲门癌相关（HR，1.23; 95% CI，1.04 - 1.45;异质性，I2 = 36.4，P = 0.207）。在剂量反应分析中，咖啡摄入量（杯）与胃癌风险之间没有显著相关性（线性趋势和非线性P> 0.05）。我们的荟萃分析表明，咖啡消费与总体胃癌风险无关;然而，咖啡消费可能是贲门癌的危险因素。
Results from observational epidemiologic studies on the relationship between coffee consumption and gastric cancer are inconsistent and inconclusive. To assess the association between coffee consumption and the risk of gastric cancer, we summarized evidence from prospective cohort studies. Relevant studies were retrieved through computer searches (PubMed, EmBase and the Cochrane Library) and a review of references up to December 2014. The quality of the included studies was evaluated by Newcastle-Ottawa quality assessment scale. We used a meta-analytic approach to estimate overall hazard ratios (HRs) and 95% confidence intervals (CIs) for regular coffee drinkers versus individuals who seldom drank coffee. Sensitivity analysis and subgroup analysis were performed to assess the reliability of our results. A dose–response analysis was performed to assess the risk of gastric cancer based on the level of coffee consumption. Nine prospective cohort studies involving 1,250,825 participants and 3027 gastric cancer cases were included in this meta-analysis. The pooled HR of gastric cancer for the study-specific regularly versus seldom coffee drinking categories was 1.05 (95% CI, 0.88 to 1.25) with significant heterogeneity across studies (I2 = 74.0%, P = 0.000). After the sensitivity analysis, three studies were deleted; however the association remained insignificant (HR, 0.99; 95% CI, 0.91 to 1.08). Subgroup analysis by anatomic location showed a risk for coffee consumption associated with cardia cancer (HR, 1.23; 95% CI, 1.04 to 1.45; heterogeneity, I2 = 36.4, P = 0.207). In the dose–response analysis, there was no significant association between coffee intake (in cups) and the risk of gastric cancer (P for linearity trend and non-linearity > 0.05). Our meta-analysis demonstrated that coffee consumption was not associated with overall gastric cancer risk; however, coffee consumption may be a risk factor for gastric cardia cancer.
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DOI：
10.1158/1055-9965.epi-13-0886
发表时间：
2014-04
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Ainslie-Waldman CE;Koh WP;Jin A;Yeoh KG;Zhu F;Wang R;Yuan JM;Butler LM
通讯作者：
Butler LM
影响因子：
5
作者：
GREENLAND, S;LONGNECKER, MP
通讯作者：
LONGNECKER, MP
影响因子：
8.4
作者：
Ferro, Ana;Peleteiro, Barbara;Lunet, Nuno
通讯作者：
Lunet, Nuno
影响因子：
2.3
作者：
Nilsson, Lena Maria;Johansson, Ingegerd;Van Guelpen, Bethany
通讯作者：
Van Guelpen, Bethany
DOI：
10.1016/0197-2456(86)90046-2
发表时间：
1986-09-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
DERSIMONIAN, R;LAIRD, N
通讯作者：
LAIRD, N