Brain tissue responses to neural implants impact signal sensitivity and intervention strategies.
Brain tissue responses to neural implants impact signal sensitivity and intervention strategies.
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DOI：
10.1021/cn500256e
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发表时间：
2015-01-21
影响因子：
5
通讯作者：
Cui, X. Tracy
中科院分区：
文献类型：
--
作者：
Kozai, Takashi D. Y.;Jaquins-Gerstl, Andrea S.;Vazquez, Alberto L.;Michael, Adrian C.;Cui, X. Tracy
植入式生物传感器是基础神经科学研究和临床应用的宝贵科学工具。神经技术提供神经信号和神经化学过程的直接读数。这些工具通常是最有价值的，当性能的能力延长数月和数年，以促进记忆，可塑性和行为的研究或监测病人的条件。这些需求产生了各种各样的设备设计，从用于快速扫描循环伏安法（FSCV）和电生理学的微电极到用于采样和检测各种神经化学物质的微透析探针。无论使用哪种技术，插入器械时突破血脑屏障（BBB）都会触发一系列生化途径，导致对植入器械的复杂分子和细胞反应。植入物周围微环境中的分子和细胞变化包括引入机械应变、神经胶质细胞活化、灌注丧失、继发性代谢损伤和神经元变性。随着时间的推移，器械周围组织微环境的变化会显著影响电化学和电生理信号的灵敏度和稳定性。这篇综述总结了最先进的植入式装置引起的动态分子和细胞水平神经组织反应的幅度，变异性和时间过程。研究表明，插入损伤和异物反应会在急性期（数秒至数分钟）和慢性期（数周至数月）不同程度地影响所有植入的中枢神经系统（CNS）传感器的信号质量。了解脑组织在细胞和分子水平上对设备的反应背后的潜在生物学过程，会导致各种干预策略，以提高信号灵敏度和寿命。
Implantable biosensors are valuable scientific tools for basic neuroscience research and clinical applications. Neurotechnologies provide direct readouts of neurological signal and neurochemical processes. These tools are generally most valuable when performance capacities extend over months and years to facilitate the study of memory, plasticity, and behavior or to monitor patients’ conditions. These needs have generated a variety of device designs from microelectrodes for fast scan cyclic voltammetry (FSCV) and electrophysiology to microdialysis probes for sampling and detecting various neurochemicals. Regardless of the technology used, the breaching of the blood–brain barrier (BBB) to insert devices triggers a cascade of biochemical pathways resulting in complex molecular and cellular responses to implanted devices. Molecular and cellular changes in the microenvironment surrounding an implant include the introduction of mechanical strain, activation of glial cells, loss of perfusion, secondary metabolic injury, and neuronal degeneration. Changes to the tissue microenvironment surrounding the device can dramatically impact electrochemical and electrophysiological signal sensitivity and stability over time. This review summarizes the magnitude, variability, and time course of the dynamic molecular and cellular level neural tissue responses induced by state-of-the-art implantable devices. Studies show that insertion injuries and foreign body response can impact signal quality across all implanted central nervous system (CNS) sensors to varying degrees over both acute (seconds to minutes) and chronic periods (weeks to months). Understanding the underlying biological processes behind the brain tissue response to the devices at the cellular and molecular level leads to a variety of intervention strategies for improving signal sensitivity and longevity.
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DOI：
10.1523/jneurosci.5094-09.2010
发表时间：
2010-04-28
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bowton E;Saunders C;Erreger K;Sakrikar D;Matthies HJ;Sen N;Jessen T;Colbran RJ;Caron MG;Javitch JA;Blakely RD;Galli A
通讯作者：
Galli A
影响因子：
15.9
作者：
Chabot, S;Williams, G;Yong, VW
通讯作者：
Yong, VW
DOI：
10.1016/0736-5748(93)90072-l
发表时间：
1993-04-01
影响因子：
1.8
作者：
BERNSTEIN, JJ;WILLINGHAM, LA;GOLDBERG, WJ
通讯作者：
GOLDBERG, WJ
影响因子：
12.7
作者：
BENVENISTE, H;DIEMER, NH
通讯作者：
DIEMER, NH
影响因子：
4.9
作者：
Cao, Lan;Chang, Mark;Horbett, Thomas A.
通讯作者：
Horbett, Thomas A.