Targeting Insulin Resistance to Treat Cognitive Dysfunction.
Targeting Insulin Resistance to Treat Cognitive Dysfunction.
复制标题
靶向胰岛素抵抗治疗认知功能障碍。
DOI：
10.1007/s12035-021-02283-3
复制
发表时间：
2021-06
影响因子：
5.1
通讯作者：
Pugazhenthi, Subbiah
中科院分区：
文献类型：
--
作者：
Tyagi, Anit;Pugazhenthi, Subbiah
痴呆症是一种与衰老有关的毁灭性疾病。阿尔茨海默病是最常见的痴呆症，其次是血管性痴呆。除了临床诊断的痴呆症外，还报告了糖尿病患者的认知功能障碍。最近的研究现在开始认识到以慢性高血糖和胰岛素抵抗为特征的2型糖尿病是阿尔茨海默病和其他认知障碍的危险因素。虽然对胰岛素作用的研究传统上仍停留在外周组织领域，但最近的临床和临床前研究越来越多地报道了中枢神经系统中胰岛素抵抗对认知功能障碍的不利影响。这些研究的结果表明，抗糖尿病药物有可能用于治疗痴呆症。在这篇综述中，我们讨论了胰岛素在大脑中的生理功能，胰岛素抵抗条件下认知功能的评价研究，并报道了抗糖尿病药物在大脑中的有益作用。这篇综述涵盖了临床研究以及动物模型的研究，并将进一步强调胰岛素抵抗和神经退行性疾病之间的联系。
Dementia is a devastating disease associated with aging. Alzheimer’s disease is the most common form of dementia, followed by vascular dementia. In addition to clinically diagnosed dementia, cognitive dysfunction has been reported in diabetic patients. Recent studies are now beginning to recognize type 2 diabetes mellitus, characterized by chronic hyperglycemia and insulin resistance, as a risk factor for Alzheimer’s disease and other cognitive disorders. While studies on insulin action have remained traditionally in the domain of peripheral tissues, the detrimental effects of insulin resistance in the central nervous system on cognitive dysfunction are increasingly being reported by recent clinical and preclinical studies. The findings from these studies suggest that antidiabetic drugs have the potential to be used to treat dementia. In this review, we discuss the physiological functions of insulin in the brain, studies on the evaluation of cognitive function under conditions of insulin resistance, and reports on the beneficial actions of antidiabetic drugs in the brain. This review covers clinical studies as well as investigations in animal models and will further highlight the emerging link between insulin resistance and neurodegenerative disorders.
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DOI：
10.1038/ijo.2017.231
发表时间：
2018-03
期刊：
International journal of obesity (2005)
影响因子：
--
作者：
Banks WA;Farr SA;Salameh TS;Niehoff ML;Rhea EM;Morley JE;Hanson AJ;Hansen KM;Craft S
通讯作者：
Craft S
影响因子：
3.7
作者：
Benedict, C;Hallschmid, M;Kern, W
通讯作者：
Kern, W
影响因子：
5
作者：
Cao, Yue;Holscher, Christian;Qi, Jin-Shun
通讯作者：
Qi, Jin-Shun
影响因子：
6
作者：
Avgerinos KI;Kalaitzidis G;Malli A;Kalaitzoglou D;Myserlis PG;Lioutas VA
通讯作者：
Lioutas VA
影响因子：
4.6
作者：
Chang KL;Pee HN;Yang S;Ho PC
通讯作者：
Ho PC