Dopamine and serotonin interplay for valence-based spatial learning.
Dopamine and serotonin interplay for valence-based spatial learning.
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DOI：
10.1016/j.celrep.2022.110645
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发表时间：
2022-04-12
期刊：
影响因子：
8.8
通讯作者：
Clopath, Claudia
中科院分区：
文献类型：
--
作者：
Wert-Carvajal, Carlos;Reneaux, Melissa;Tchumatchenko, Tatjana;Clopath, Claudia
多巴胺（DA）和5-羟色胺（5-HT）是突触可塑性的重要神经调节剂，与积极或消极结果的学习或基于效价的学习有关。在海马体中，两者都影响长期可塑性，但在编码不确定性或预测奖励方面发挥不同的作用。DA与正效价相关，从奖励消费或回避行为，5-HT到厌恶编码。我们建议DA产生整体LTP，而5-HT elephant LTD。在这里，我们比较两个奖励调制的尖峰时间依赖可塑性（R-STDP）的规则来描述这些神经调质的行动。我们研究了它们在Morris水迷宫任务和逆转学习的计算模型的认知表现和灵活性中的作用。我们的研究结果表明，DA和5-HT的相互作用提高了学习成绩，可以解释实验证据。这项研究强调了神经调节在确定可塑性方向方面的重要性。DA和5-HT的可塑性模型可以再现海马基于效价的学习行为。无论是顺序性还是相加性，DA和5-HT的相互作用都有不同的结果。表明DA和5-HT拮抗作用的奖赏调制可塑性模型可以解释海马中的效价学习。他们对5-HT进行光遗传学操作的结果再现了Morris水迷宫行为。此外，他们还提供了关于反向学习的实验可证明的预测。
Dopamine (DA) and serotonin (5-HT) are important neuromodulators of synaptic plasticity that have been linked to learning from positive or negative outcomes or valence-based learning. In the hippocampus, both affect long-term plasticity but play different roles in encoding uncertainty or predicted reward. DA has been related to positive valence, from reward consumption or avoidance behavior, and 5-HT to aversive encoding. We propose DA produces overall LTP while 5-HT elicits LTD. Here, we compare two reward-modulated spike timing-dependent plasticity (R-STDP) rules to describe the action of these neuromodulators. We examined their role in cognitive performance and flexibility for computational models of the Morris water maze task and reversal learning. Our results show that the interplay of DA and 5-HT improves learning performance and can explain experimental evidence. This study reinforces the importance of neuromodulation in determining the direction of plasticity. Plasticity model of DA and 5-HT can reproduce hippocampal valence-based learning Interplay of DA and 5-HT has distinct outcomes, whether sequential or additive DA and 5-HT learning rules reproduce mouse behavior in the Morris water maze task Reversal learning can be represented by antagonism between DA and 5-HT Wert-Carvajal et al. show that a reward-modulated plasticity model of DA and 5-HT antagonism can explain learning by valence in the hippocampus. Their results with optogenetic manipulations of 5-HT reproduce Morris water maze behavior. In addition, they provide experimentally provable predictions regarding reversal learning.
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海马中的5-羟色胺受体。
影响因子：
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作者：
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影响因子：
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