Psychosocial stress augments tumor development through beta-adrenergic activation in mice.
Psychosocial stress augments tumor development through beta-adrenergic activation in mice.
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DOI：
10.1111/j.1349-7006.2002.tb01313.x
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发表时间：
2002-07
期刊：
影响因子：
--
通讯作者：
Saiki I
中科院分区：
文献类型：
--
作者：
Hasegawa H;Saiki I
饲养条件影响动物的行为和生物反应。我们研究了同性别分组（G）、拥挤（GC）和隔离（I）条件对植入同基因雄性C57 BL/6或BALB/c小鼠足垫中的B16黑色素瘤或甲硫氨酸A纤维肉瘤生长的影响。差异住房改变宿主对肿瘤生长的抵抗力。宿主对应激的反应反映在胸腺萎缩中，胸腺萎缩在G小鼠中最低，在GC小鼠中最高，在I小鼠中居中。GC条件是一个更紧张的社会环境比我的条件在雄性C57 BL/6和BALB/c小鼠。反映心理社会应激的程度，肿瘤生长增加的GC，I和G条件的顺序，并观察到肿瘤和胸腺之间的负质量相关性，从而清楚地表明，宿主对肿瘤的抵抗力减弱的心理社会应激。此外，通过口服非选择性β-肾上腺素能拮抗剂普萘洛尔完全消除了应激增强的肿瘤生长和胸腺萎缩。相反，皮质酮的长期给药显著诱导胸腺和脾脏萎缩，而不影响肿瘤的生长。这些结果表明心理社会应激、肿瘤生长和β-肾上腺素能激活之间存在相互关系。
Housing conditions affect behavioral and biological responses of animals. We investigated the effect of same‐sex‐grouped (G), crowded (GC) and isolated (I) conditions on the growth of B16 melanoma or Meth A fibrosarcoma implanted in the footpad of syngeneic male C57BL/6 or BALB/c mice. Differential housing altered host resistance to tumor growth. The host responses to stress were reflected in thymic atrophy, which was lowest in the G mice, highest in the GC mice and intermediate in the I mice. The GC condition was a more stressful social environment than the I condition in both male C57BL/6 and BALB/c mice. Reflecting the extent of psychosocial stress, tumor growth was augmented in the order of GC, I and G condition, and a negative mass correlation between tumor and thymus was observed, thus clearly indicating that the host resistance to tumors was attenuated by psychosocial stress. Furthermore, the stress‐enhanced tumor growth and thymus atrophy were completely abrogated by the oral administration of the non‐selective β‐adrenergic antagonist, propranolol. On the contrary, the chronic administration of corticosterone significantly induced the atrophy of thymus and spleen without affecting tumor growth. These results suggest an interrelationship among psychosocial stress, tumor growth and β‐adrenergic activation.
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影响因子：
8.8
作者：
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通讯作者：
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影响因子：
2.4
作者：
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DOI：
10.1097/00004850-199809005-00005
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