Cognitive changes and neural correlates after oral rehabilitation procedures in older adults: a protocol for an interventional study.
Cognitive changes and neural correlates after oral rehabilitation procedures in older adults: a protocol for an interventional study.
复制标题
DOI：
10.1186/s12903-021-01654-5
复制
发表时间：
2021-06-09
期刊：
影响因子：
2.9
通讯作者：
Trulsson M
中科院分区：
文献类型：
--
作者：
Hedberg L;Ekman U;Nordin LE;Smedberg JI;Skott P;Seiger Å;Sandborgh-Englund G;Westman E;Kumar A;Trulsson M
流行病学研究表明咀嚼功能和认知障碍之间存在关联。这进一步加强了牙齿脱落和咀嚼功能受损可能是痴呆症和认知能力下降的风险因素的概念。动物实验表明了因果关系，并讨论了几种可能的机制。然而，这一证据在人类身上是缺乏的。因此，在目前的干预性研究中，我们的目的是探讨咀嚼功能康复对老年人认知的影响。将80名需要进行口腔修复的患者随机分配到实验组或对照组。参与者将在口腔康复前、3个月和1年后进行神经心理学评估、咀嚼能力测试、唾液测试、可选的磁共振成像，并回答口腔健康影响概况和医院焦虑和抑郁量表的问卷。两组之间的差异在于，对照组将在口腔康复程序开始之前进行额外的测试（间隔约3个月）。主要结果是情景记忆表现的测量变化。虽然牙齿脱落和咀嚼功能在老年人中很普遍，但它仍然是一个未被充分研究的可改变的风险因素，可能会导致认知障碍的发展。如果咀嚼功能康复对神经认知功能有积极的影响，这将对咀嚼功能受损患者的未来保健具有重要意义。本项目可能为预防老年人认知能力下降提供新的途径。试验注册：研究方案回顾性注册于www.example.com标识符：NCT 04458207，日期：2020年2月7日。
Epidemiological studies show an association between masticatory function and cognitive impairment. This has further strengthened the notion that tooth loss and impaired masticatory function may be risk factors for dementia and cognitive decline. Animal experiments have indicated a causal relationship and several possible mechanisms have been discussed. This evidence is, however, lacking in humans. Therefore, in the current interventional study, we aim to investigate the effect of rehabilitation of masticatory function on cognition in older adults. Eighty patients indicated for prosthodontic rehabilitation will be randomly assigned to an experimental or a control group. Participants will conduct neuropsychological assessments, masticatory performance tests, saliva tests, optional magnetic resonance imaging, and answer questionnaires on oral health impact profiles and hospital anxiety and depression scale before, 3 months, and 1 year after oral rehabilitation. The difference between the two groups is that the control group will be tested an additional time, (at an interval of about 3 months) before the onset of the oral rehabilitation procedure. The primary outcome is a change in measures of episodic memory performance. Although tooth loss and masticatory function are widespread in older people, it is still an underexplored modifiable risk factor potentially contributing to the development of cognitive impairment. If rehabilitation of masticatory function shows positive effects on the neurocognitive function, this will have great implications on future health care for patients with impaired masticatory status. The present project may provide a new avenue for the prevention of cognitive decline in older individuals. Trial registration: The protocol for the study was retrospectively registered in ClinicalTrials.gov Identifier: NCT04458207, dated 02-07-2020.
登录
查看更多内容
影响因子：
1.9
作者：
Habib, Reza;Nyberg, Lars;Nilsson, Lars-Goran
通讯作者：
Nilsson, Lars-Goran
影响因子：
3.5
作者：
Aoki, H;Kimoto, K;Toyoda, M
通讯作者：
Toyoda, M
影响因子：
2.9
作者：
Deng, Hongyan;Gao, Shang;Svensson, Peter
通讯作者：
Svensson, Peter
影响因子：
4.6
作者：
Grigoriadis, Joannis;Kumar, Abhishek;Trulsson, Mats
通讯作者：
Trulsson, Mats
影响因子：
11
作者：
Houx, PJ;Shepherd, J;Westendorp, RG
通讯作者：
Westendorp, RG