Environmental triggers of Parkinson's disease - Implications of the Braak and dual-hit hypotheses.
Environmental triggers of Parkinson's disease - Implications of the Braak and dual-hit hypotheses.
复制标题
DOI：
10.1016/j.nbd.2021.105601
复制
发表时间：
2022-02
影响因子：
6.1
通讯作者：
Killinger, Bryan
中科院分区：
文献类型：
--
作者：
Chen, Honglei;Wang, Keran;Scheperjans, Filip;Killinger, Bryan
特发性帕金森病（PD）可能需要数十年的发展，在此期间，许多风险或保护因素可能会开始发挥作用，以启动发病机制或改变其进展为临床PD。对帕金森病前驱期及其相关因素的认识不足一直是帕金森病病因学和预防策略研究的主要障碍。尽管仍存在争议，但Braak和双重打击假说认为PD可能在嗅觉结构和/或肠道中从外周开始，这为识别PD前驱发展和进展的触发因素和调节因素提供了理论平台。这对于PD的环境原因的搜索尤其如此，因为嗅觉结构和肠道是人类与环境的主要粘膜界面。在这篇综述中，我们提出了我们个人的观点，关于Braak和双重打击假设如何帮助我们寻找PD的环境触发因素和修饰剂，总结现有的实验和流行病学证据，并讨论研究差距和策略。
Idiopathic Parkinson’s disease (PD) may take decades to develop, during which many risk or protective factors may come into play to initiate the pathogenesis or modify its progression to clinical PD. The lack of understanding of this prodromal phase of PD and the factors involved has been a major hurdle in the study of PD etiology and preventive strategies. Although still controversial, the Braak and dual-hit hypotheses that PD may start peripherally in the olfactory structures and/or the gut provides a theoretical platform to identify the triggers and modifiers of PD prodromal development and progression. This is particularly true for the search of environmental causes of PD as the olfactory structures and gut are the major human mucosal interfaces with the environment. In this review, we lay out our personal views about how the Braak and dual-hit hypotheses may help us search for the environmental triggers and modifiers for PD, summarize available experimental and epidemiological evidence, and discuss research gaps and strategies.
登录
查看更多内容
影响因子：
2.9
作者：
Lee SJ;Kim EM;Cho SH;Song J;Jang TW;Lee MY
通讯作者：
Lee MY
影响因子：
8.6
作者：
Lucassen, Elisabeth B.;Sterling, Nicholas W.;Lee, Eun-Young;Chen, Honglei;Lewis, Mechelle M.;Kong, Lan;Huang, Xuemei
通讯作者：
Huang, Xuemei
影响因子：
6.3
作者：
AHLSTROM, R;BERGLUND, B;WENNBERG, A
通讯作者：
WENNBERG, A
影响因子：
15.1
作者：
Aho VTE;Houser MC;Pereira PAB;Chang J;Rudi K;Paulin L;Hertzberg V;Auvinen P;Tansey MG;Scheperjans F
通讯作者：
Scheperjans F
影响因子：
9.9
作者：
Antunes, Marcelo B.;Bowler, Rosemarie;Doty, Richard L.
通讯作者：
Doty, Richard L.