History of smoking and olfaction in Parkinson's disease.
History of smoking and olfaction in Parkinson's disease.
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DOI：
10.1002/mds.25912
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发表时间：
2014-07
影响因子：
8.6
通讯作者：
Huang, Xuemei
中科院分区：
文献类型：
--
作者：
Lucassen, Elisabeth B.;Sterling, Nicholas W.;Lee, Eun-Young;Chen, Honglei;Lewis, Mechelle M.;Kong, Lan;Huang, Xuemei
嗅觉功能障碍是帕金森病最常见的运动前症状，众所周知，吸烟与帕金森病的风险较低有关。这项研究检验了吸烟与帕金森病患者更好的嗅觉相关的假设。吸烟史来自 76 名 PD 受试者 [22 名有吸烟史（吸烟者），54 名从不吸烟者（非吸烟者）] 和 70 名对照者（17 名吸烟者，53 名不吸烟者）。使用 40 项宾夕法尼亚大学气味识别测试 (UPSIT) 评估嗅觉。使用协方差分析比较各组和亚组之间的嗅觉评分，并调整年龄、性别和 MAO-B 抑制剂的使用情况。总体而言，与对照组相比，PD 中的嗅觉评分较低（嗅觉评分：21.54 vs. 33.45，p<0.0001）。在对照组中，吸烟者和非吸烟者之间的嗅觉没有显着差异（嗅觉得分：33.2 vs. 34.2，p = 0.95）。然而，在 PD 受试者中，吸烟者的嗅觉得分明显高于非吸烟者（嗅觉得分：24.4 比 19.9，p=0.02）。这些数据表明，吸烟史与 PD 患者更好的嗅觉有关。这一发现可能与吸烟可以预防帕金森病有关。需要进一步的研究来证实这一发现并调查潜在的机制。
Olfactory dysfunction is the most common pre-motor symptom in Parkinson’s disease, and smoking is known to be associated with lower risk of PD. This study tested the hypothesis that smoking is associated with better olfaction in PD. Smoking history was obtained from 76 PD subjects [22 with a history of smoking (smokers), 54 who never smoked (non-smokers)], and 70 Controls (17 smokers, 53 non-smokers). Olfaction was assessed using the 40-item University of Pennsylvania Smell Identification Test (UPSIT). The olfactory scores between groups and subgroups were compared using analysis of covariance with adjustment for age, gender, and MAO-B inhibitor usage. Overall the olfactory score was lower in PD compared to Controls (olfactory scores: 21.54 vs. 33.45, p<0.0001). Among Controls, there was no significant difference in olfaction between smokers and non-smokers (olfactory scores: 33.2 vs. 34.2, p=0.95). Among PD subjects, however, smokers scored significantly better regarding olfaction compared to non-smokers (olfactory scores: 24.4 vs. 19.9, p=0.02). These data suggest that history of smoking is associated with better olfaction among PD patients. The finding may be related to why smoking may be protective against PD. Further studies are needed to confirm this finding and investigate the underlying mechanism(s).
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