Tetraploidy in cancer and its possible link to aging.
Tetraploidy in cancer and its possible link to aging.
复制标题
DOI：
10.1111/cas.13717
复制
发表时间：
2018-09
期刊：
影响因子：
5.7
通讯作者：
Inagaki M
中科院分区：
文献类型：
--
作者：
Tanaka K;Goto H;Nishimura Y;Kasahara K;Mizoguchi A;Inagaki M
四倍体是一种细胞具有四组同源染色体的情况，通常被视为一种自然生理状况，但也经常出现在病理生理状况如癌症中。四倍体促进染色体不稳定性（CIN），其是升高水平的染色体丢失和获得，其可导致产生携带染色体的结构和数目畸变的多种非整倍体细胞。由此产生的基因组异质性，据推测加速核型进化，赋予致癌潜力，尽管减少细胞的健身所造成的非整倍体。最近的研究表明，四倍体也可能与衰老有关;中间丝蛋白突变的小鼠显示，这些四倍体倾向的小鼠表现出与衰老相关的组织疾病。细胞衰老及其伴随的衰老相关分泌表型现已成为将四倍体和四倍体诱导的CIN与癌症以及可能与衰老联系起来的关键因素。在这里，我们回顾了最近关于四倍体如何与癌症和可能与衰老相关的研究结果，并讨论了这种关系的潜在机制，以及我们如何利用表现出四倍体诱导的CIN的细胞的特性来控制这些病理条件。
Tetraploidy, a condition in which a cell has four homologous sets of chromosomes, is often seen as a natural physiological condition but is also frequently seen in pathophysiological conditions such as cancer. Tetraploidy facilitates chromosomal instability (CIN), which is an elevated level of chromosomal loss and gain that can cause production of a wide variety of aneuploid cells that carry structural and numerical aberrations of chromosomes. The resultant genomic heterogeneity supposedly expedites karyotypic evolution that confers oncogenic potential in spite of the reduced cellular fitness caused by aneuploidy. Recent studies suggest that tetraploidy might also be associated with aging; mice with mutations in an intermediate filament protein have revealed that these tetraploidy‐prone mice exhibit tissue disorders associated with aging. Cellular senescence and its accompanying senescence‐associated secretory phenotype have now emerged as critical factors that link tetraploidy and tetraploidy‐induced CIN with cancer, and possibly with aging. Here, we review recent findings about how tetraploidy is related to cancer and possibly to aging, and discuss underlying mechanisms of the relationship, as well as how we can exploit the properties of cells exhibiting tetraploidy‐induced CIN to control these pathological conditions.
登录
查看更多内容
影响因子：
64.8
作者：
Bartkova, Jirina;Rezaei, Nousin;Gorgoulis, Vassilis G.
通讯作者：
Gorgoulis, Vassilis G.
影响因子：
64.8
作者：
Di Micco, Raffaella;Fumagalli, Marzia;di Fagagna, Fabrizio d'Adda
通讯作者：
di Fagagna, Fabrizio d'Adda
影响因子：
64.5
作者：
Davoli T;Xu AW;Mengwasser KE;Sack LM;Yoon JC;Park PJ;Elledge SJ
通讯作者：
Elledge SJ
染色体不稳定性通过胞质DNA反应驱动转移。
影响因子：
64.8
作者：
Bakhoum SF;Ngo B;Laughney AM;Cavallo JA;Murphy CJ;Ly P;Shah P;Sriram RK;Watkins TBK;Taunk NK;Duran M;Pauli C;Shaw C;Chadalavada K;Rajasekhar VK;Genovese G;Venkatesan S;Birkbak NJ;McGranahan N;Lundquist M;LaPlant Q;Healey JH;Elemento O;Chung CH;Lee NY;Imielenski M;Nanjangud G;Pe'er D;Cleveland DW;Powell SN;Lammerding J;Swanton C;Cantley LC
通讯作者：
Cantley LC
影响因子：
9.2
作者：
Chan JY
通讯作者：
Chan JY