CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet.
CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet.
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时钟基因与参加基于地中海饮食的饮食计划的肥胖患者的体重减轻有关。
DOI：
10.1038/ijo.2009.255
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发表时间：
2010-03
影响因子：
4.9
通讯作者：
Ordovas, J. M.
中科院分区：
文献类型：
--
作者：
Garaulet, M.;Corbalan, M. D.;Madrid, J. A.;Morales, E.;Baraza, J. C.;Lee, Y. C.;Ordovas, J. M.
肥胖治疗的成功取决于患者的遗传背景。昼夜节律运动输出周期 Kaput (CLOCK) 是分子钟正肢的转录因子之一，参与代谢改变。旨在调查 CLOCK 的五个候选多态性是否与人体测量、代谢测量和体重减轻相关，以响应基于地中海饮食的行为减肥计划。研究人员对 500 名年龄在 20-65 岁之间、就诊于肥胖症专科门诊的超重/肥胖受试者进行了研究。分析了人体测量、生化和饮食摄入变量。评估了该计划的有效性以及 28 周治疗期间的减肥进展。所选的 5 个 CLOCK SNP 中有 4 个与肥胖变量显着相关 (P<0.05)。 rs1801260 CLOCK 的遗传变异与基线肥胖相关，也影响体重减轻。与野生型相比，携带变异等位基因 (G) 的患者体重明显减轻 (P = 0.008)。重复测量分析表明，随着时间的推移，rs1801260 CLOCK 变异之间的体重减轻存在显着差异（P = 0.038）。 G等位基因携带者比非携带者在减肥方面表现出更大的困难。在这种特殊的多态性中，次要等位基因携带者短时间睡眠（每天≤6小时）的频率高于非携带者（59% vs 41%；P<0.05）。 CLOCK 多态性还与饮食治疗完成时血浆总胆固醇的显着差异相关（P<0.05）。我们重复了之前的研究，显示了 CLOCK 基因多态性与肥胖之间的关系。 CLOCK rs1801260 SNP 可以预测基于低能量饮食的体重减轻策略的结果。
The success of obesity therapy is dependent on the genetic background of the patient. Circadian Locomotor Output Cycles Kaput (CLOCK), one of the transcription factors from the positive limb of the molecular clock, is involved in metabolic alterations. To investigate whether five candidate polymorphisms from CLOCK were associated with anthropometric, metabolic measures and weight loss in response to a behavioural weight reduction programme based on the Mediterranean diet. Five hundred overweight/obese subjects, aged 20–65 years, who attended outpatient clinics specializing in obesity, were studied. Anthropometric, biochemical and dietary intake variables were analysed. Effectiveness of the programme and weight loss progression during 28 weeks of treatment was assessed. Four of five CLOCK SNPs selected were significantly associated with obesity variables (P<0.05). The genetic variation in the rs1801260 CLOCK was associated with obesity at baseline and also affected weight loss. Patients with the variant allele (G) lost significantly less weight i(P = 0.008) compared with wild type. Repeated measures analysis showed that weight loss over time was significantly different between rs1801260 CLOCK variations (P = 0.038). Carriers of the G allele displayed greater difficulty in losing weight than non-carriers. In this particular polymorphism, the frequency of short-time sleepers (≤6 h per day) was greater in minor allele carriers than in non-carriers (59% vs 41%; P<0.05). CLOCK polymorphisms were also associated with significant differences in total plasma cholesterol at the completion of dietary treatment (P<0.05). We have replicated previous studies showing a relationship between CLOCK gene polymorphisms and obesity. CLOCK rs1801260 SNP may predict the outcome of body weight reduction strategies based on low-energy diets.
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影响因子：
30.8
作者：
de Bakker, PIW;Yelensky, R;Altshuler, D
通讯作者：
Altshuler, D
影响因子：
2.5
作者：
Benedetti, F.;Radaelli, D.;Smeraldi, E.
通讯作者：
Smeraldi, E.
影响因子：
2.5
作者：
Monteleone, Palmiero;Tortorella, Alfonso;Maj, Mario
通讯作者：
Maj, Mario
影响因子：
2.8
作者：
Lee, Heon-Jeong;Paik, Jong-Woo;Kim, Leen
通讯作者：
Kim, Leen
影响因子：
3.2
作者：
Serra-Majem, L;Aranceta, J
通讯作者：
Aranceta, J