DNA circuits compatible encoder and demultiplexer based on a single biomolecular platform with DNA strands as outputs.
DNA circuits compatible encoder and demultiplexer based on a single biomolecular platform with DNA strands as outputs.
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DNA 电路兼容的编码器和解复用器基于单个生物分子平台，以 DNA 链作为输出
DOI：
10.1093/nar/gkac650
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发表时间：
2022-08-26
影响因子：
14.9
通讯作者：
Wu, Tongbo
中科院分区：
文献类型：
--
作者：
Xie, Tianci;Deng, Yuhan;Zhang, Jiarui;Zhang, Zhen;Hu, Zhe;Wu, Tongbo
构建了一系列基于单个生物分子平台的多逻辑电路来实现非算术和算术功能，包括4对2编码器、1对2解复用器、1对4解复用器和多输入或门。DNA回路的编码者相当于反射弧形的感官感受器。它们的功能都是将来自通路外部(DNA回路或反射弧)的信息编码成一种后续通路可以识别和利用的形式。目前的分子编码器是基于光或电信号作为输出，而DNA电路是基于DNA链作为传输信号。现有编码器的输出不能被后续的DNA电路识别。这是第一次将以DNA链为输出的基于DNA的编码器真正应用于DNA电路，使DNA电路能够在非二进制生物环境中应用。所设计的系统的另一个新特点是，所开发的纳米器件都具有结构简单、低泄漏和低串扰的特点，这使得它们能够轻松地实现更高级别的编解复用器。我们的工作是基于简单形式的复杂功能的思想，这也将为开发先进的分子逻辑电路提供一条新的途径。一个‘n-n’TJDH，它可以处理n个输入，并产生n个输出。以DNA链为输出的分子编码器由TJDH组装而成。
A series of multiple logic circuits based on a single biomolecular platform is constructed to perform nonarithmetic and arithmetic functions, including 4-to-2 encoder, 1-to-2 demultiplexer, 1-to-4 demultiplexer, and multi-input OR gate. The encoder to a DNA circuit is the equivalent of a sensory receptor to a reflex arc. They all function to encode information from outside the pathway (DNA circuit or reflex arc) into a form that subsequent pathways can recognize and utilize. Current molecular encoders are based on optical or electrical signals as outputs, while DNA circuits are based on DNA strands as transmission signals. The output of existing encoders cannot be recognized by subsequent DNA circuits. It is the first time the DNA-based encoder with DNA strands as outputs can be truly applied to the DNA circuit, enabling the application of DNA circuits in non-binary biological environments. Another novel feature of the designed system is that the developed nanodevices all have a simple structure, low leakage and low crosstalk, which allows them to implement higher-level encoders and demultiplexers easily. Our work is based on the idea of complex functionality in a simple form, which will also provide a new route for developing advanced molecular logic circuits. An ‘n–n’ TJDH which could deal with n inputs, and produce n outputs. The molecular encoder with DNA strands as outputs is assembled by TJDHs.
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