Community Violence Exposure is Associated with Hippocampus-Insula Resting State Functional Connectivity in Urban Youth.
Community Violence Exposure is Associated with Hippocampus-Insula Resting State Functional Connectivity in Urban Youth.
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DOI：
10.1016/j.neuroscience.2021.06.010
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发表时间：
2021-08-01
期刊：
影响因子：
3.3
通讯作者：
Jovanovic T
中科院分区：
文献类型：
--
作者：
Reda MH;Marusak HA;Ely TD;van Rooij SJH;Stenson AF;Stevens JS;France JM;Tottenham N;Jovanovic T
我们之前的工作已经将黑人青年的童年暴力暴露与海马体的功能变化联系起来，海马体是大脑中对压力敏感的区域。然而，不同的暴力环境（如社区、家庭、学校）可能对神经回路产生不同的影响。我们研究了社区暴力在预测海马体静息状态功能连接（rsFC）方面的独特作用。52名（26F） 8-15岁有暴力经历的黑人青年在睁着眼睛注视固定十字架7分钟的同时进行了静息状态功能神经成像扫描。研究人员进行了基于种子的分析，以检验总暴力暴露与海马体对整个大脑的rsFC之间的关系。对社区暴力行为进行后续层次回归分析。暴力暴露与具有默认模式网络核心节点（即后扣带皮层）的较高海马rsFC和具有突出网络核心节点（即脑岛）的较低海马rsFC相关。在控制了家庭和学校暴力、性别和年龄之后，社区暴力与海马体-脑岛rsFC降低有独特的关联。与年龄相关的海马体-脑岛rsFC减少也存在于暴力暴露程度较低的青少年中，但不存在于暴力暴露程度较高的青少年中。这是第一批调查社区暴力对威胁回路的独特影响的研究之一，高于家庭和学校暴力。我们的数据表明，在暴力暴露的青少年中，海马体的功能发生了变化，与青少年经历的其他形式的暴力相比，社区暴力可能是一种更显著的威胁暴露形式。
Our previous work has linked childhood violence exposure in Black youth to functional changes in the hippocampus, a brain region sensitive to stress. However, different contexts of violence exposure (e.g., community, home, school) may have differential effects on circuitry. We investigated the unique effect of community violence in predicting resting-state functional connectivity (rsFC) in the hippocampus. Fifty-two (26F) violence-exposed Black youth ages 8–15 performed resting-state functional neuroimaging scans while looking at a fixation cross for seven minutes with eyes open. Seed-based analyses were conducted to examine the association between total violence exposure and rsFC of the hippocampus to the whole brain. Follow-up hierarchical regression analysis were performed to specifically investigate community violence. Violence exposure was associated with higher hippocampus rsFC with a core node of the Default Mode Network (i.e., posterior cingulate cortex) and lower hippocampal rsFC with a core node of the Salience Network (i.e., insula). Community violence uniquely associated with lower hippocampus-insula rsFC, after controlling for home and school violence, sex and age. Age-related decreases in hippocampus-insula rsFC were also present in youth with lower violence exposure, but not in youth with higher violence exposure. This is one of the first studies to investigate the unique impact of community violence, above home and school violence, on threat circuitry. Our data suggest functional alterations in the hippocampus in violence-exposed youth, and that violence in the community may be a more salient form of threat exposure compared to other forms of violence experienced by youth.
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影响因子：
4.7
作者：
Jovanovic T;Kazama A;Bachevalier J;Davis M
通讯作者：
Davis M
影响因子：
4.2
作者：
Marusak, Hilary A.;Etkin, Amit;Thomason, Moriah E.
通讯作者：
Thomason, Moriah E.
影响因子：
3.2
作者：
Kalisch, R;Wiech, K;Dolan, RJ
通讯作者：
Dolan, RJ
影响因子：
8
作者：
Finkelhor, David;Turner, Heather;Hamby, Sherry L.
通讯作者：
Hamby, Sherry L.
影响因子：
16.4
作者：
FINKELHOR, D;DZIUBALEATHERMAN, J
通讯作者：
DZIUBALEATHERMAN, J