Disrupted insula-based neural circuit organization and conflict interference in trauma-exposed youth.
Disrupted insula-based neural circuit organization and conflict interference in trauma-exposed youth.
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DOI：
10.1016/j.nicl.2015.04.007
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发表时间：
2015
影响因子：
4.2
通讯作者：
Thomason, Moriah E.
中科院分区：
文献类型：
--
作者：
Marusak, Hilary A.;Etkin, Amit;Thomason, Moriah E.
童年创伤暴露是精神病理学的一个潜在风险因素。新出现的研究表明，异常显著加工是早期创伤暴露与后来的认知和社会情绪缺陷之间的联系的基础，这些缺陷是几种精神障碍的标志。在这里，我们检查了在面孔分类冲突任务中的大脑和行为反应，并将其与显著网络(SN)的内在连通性联系起来。结果显示，与年龄、性别、智商和社会人口风险相匹配的对照青年(n=19)相比，暴露于创伤的青年(n=14)的SN功能障碍具有独特的模式。我们发现，受创伤影响的年轻人更容易受到冲突干扰，这与冲突期间额叶-岛叶反应较高有关。在同一参与者中收集的静息状态功能连通性数据显示，脑岛与SN种子区域的连通性增加，这与奖励敏感性降低有关，这是应激后的一个关键风险/弹性特征。除了SN的内在连通性改变外，我们在创伤暴露的年轻人中观察到SN和默认模式网络(DMN)之间的连通性改变。这些数据揭示了在疾病的最强预测因素之一--早期生活创伤之后，大脑组织中的网络水平的破坏，并证明了观察到的神经影响与行为和特定症状维度的相关性。SN功能障碍可能是导致儿童创伤后疾病和负面结果的一种因素。在冲突期间，遭受创伤的青年更容易受到干扰。较高的冲突干扰与右侧额叶-岛叶反应增加有关。暴露在创伤中的年轻人在脑岛内表现出更高的突出网络(SN)连接性。SN功能障碍可能导致创伤后的认知和情感缺陷。
Childhood trauma exposure is a potent risk factor for psychopathology. Emerging research suggests that aberrant saliency processing underlies the link between early trauma exposure and later cognitive and socioemotional deficits that are hallmark of several psychiatric disorders. Here, we examine brain and behavioral responses during a face categorization conflict task, and relate these to intrinsic connectivity of the salience network (SN). The results demonstrate a unique pattern of SN dysfunction in youth exposed to trauma (n = 14) relative to comparison youth (n = 19) matched on age, sex, IQ, and sociodemographic risk. We find that trauma-exposed youth are more susceptible to conflict interference and this correlates with higher fronto-insular responses during conflict. Resting-state functional connectivity data collected in the same participants reveal increased connectivity of the insula to SN seed regions that is associated with diminished reward sensitivity, a critical risk/resilience trait following stress. In addition to altered intrinsic connectivity of the SN, we observed altered connectivity between the SN and default mode network (DMN) in trauma-exposed youth. These data uncover network-level disruptions in brain organization following one of the strongest predictors of illness, early life trauma, and demonstrate the relevance of observed neural effects for behavior and specific symptom dimensions. SN dysfunction may serve as a diathesis that contributes to illness and negative outcomes following childhood trauma. Youth exposed to trauma are more susceptible to interference during conflict. Higher conflict interference is related to increased right fronto-insular response. Trauma-exposed youth show higher salience network (SN) connectivity within the insula. SN dysfunction may contribute to cognitive and affective deficits following trauma.
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