Striatal Local Circuitry: A New Framework for Lateral Inhibition.

Striatal Local Circuitry: A New Framework for Lateral Inhibition.
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DOI:
10.1016/j.neuron.2017.09.019
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发表时间:
2017-10-11
期刊:
影响因子:
16.2
通讯作者:
Alvarez VA
Alvarez VA
中科院分区:
医学1区
文献类型:
--
作者:
Burke DA;Rotstein HG;Alvarez VA

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This Perspective will examine the organization of intrastriatal circuitry, review recent findings in this area, and discuss how the pattern of connectivity between striatal neurons might give rise to the behaviorally observed synergism between the direct/indirect pathway neurons. The emphasis of this Perspective is on the underappreciated role of lateral inhibition between striatal projection cells in controlling neuronal firing and shaping the output of this circuit. We review some classic studies in combination with more recent anatomical and functional findings to lay out a framework for an updated model of the local intra-striatal circuitry and its contribution to the formation of functional units of processing with the striatum and the integration and filtering of inputs to generate motor patterns and learned behaviors.
纹状体培养基神经元的功能连接组。
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