Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila.
Direct sensing of systemic and nutritional signals by haematopoietic progenitors in Drosophila.
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DOI：
10.1038/ncb2453
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发表时间：
2012-03-11
影响因子：
21.3
通讯作者：
中科院分区：
文献类型：
--
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果蝇淋巴腺是一种造血器官，其祖细胞与哺乳动物常见的髓系祖细胞或CMP最相似，它们增殖并分化为三种成熟细胞——浆细胞、晶体细胞和层状细胞——其功能与哺乳动物的髓系细胞相似。在幼虫发育的第一和早期第二阶段，淋巴腺只含有祖细胞，而在第三阶段，淋巴腺初级叶的内侧区域称为髓质区（MZ）含有这些祖细胞，而成熟的血细胞被发现并列在外围区域称为皮质区（CZ）。第三组细胞被称为后信号中心（PSC），其功能是造血生态位。与哺乳动物骨髓细胞类似，果蝇血细胞对多种应激反应，包括缺氧、感染和氧化应激。然而，髓系祖细胞如何感知系统信号来调节细胞命运的决定尚未得到很好的描述。在这里，我们发现果蝇的造血祖细胞是系统性（胰岛素）和营养（必需氨基酸）信号的直接靶点，这些系统性信号通过促进无翅（哺乳动物中的WNT）信号来维持祖细胞。我们期望这项研究将促进哺乳动物髓系祖细胞可能的直接信号感知机制的研究。
The Drosophila lymph gland is a hematopoietic organ in which progenitor cells, which are most akin to the common myeloid progenitor or CMP in mammals, proliferate and differentiate into three types of mature cells – plasmatocytes, crystal cells and lamellocytes – the functions of which are reminiscent of mammalian myeloid cells. During the first and early second instars of larval development, the lymph gland contains only progenitors, whereas in the third instar, a medial region of the primary lobe of the lymph gland called the medullary zone (MZ) contains these progenitors, while maturing blood cells are found juxtaposed in a peripheral region designated the cortical zone (CZ). A third group of cells referred to as the posterior signaling center (PSC) functions as a hematopoietic niche. Similar to mammalian myeloid cells, Drosophila blood cells respond to multiple stresses including hypoxia, infection, and oxidative stress. However, how systemic signals are sensed by myeloid progenitors to regulate cell fate determination has not been well described. Here, we show that the hematopoietic progenitors of Drosophila are direct targets of systemic (insulin) and nutritional (essential amino acid) signals, and that these systemic signals maintain the progenitors by promoting Wingless (WNT in mammals) signaling. We expect that this study will promote investigation of such possible direct signal sensing mechanisms by mammalian myeloid progenitors.
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DOI：
10.1073/pnas.0809144106
发表时间：
2009-01-27
影响因子：
11.1
作者：
Hsu, Hwei-Jan;Drummond-Barbosa, Daniela
通讯作者：
Drummond-Barbosa, Daniela
影响因子：
9.2
作者：
McLeod, Catherine J.;Wang, Lei;Wong, Chihunt;Jones, D. Leanne
通讯作者：
Jones, D. Leanne
影响因子：
64.5
作者：
Böhni, R;Riesgo-Escovar, J;Hafen, E
通讯作者：
Hafen, E
影响因子：
23.9
作者：
Lee, Jae Y.;Nakada, Daisuke;Yilmaz, Omer H.;Tothova, Zuzana;Joseph, Nancy M.;Lim, Megan S.;Gilliland, D. Gary;Morrison, Sean J.
通讯作者：
Morrison, Sean J.
影响因子：
64.8
作者：
Becker, Thomas;Loch, Gerrit;Hoch, Michael
通讯作者：
Hoch, Michael