Ferroptosis: A new insight for treatment of acute kidney injury.
Ferroptosis: A new insight for treatment of acute kidney injury.
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铁死亡：治疗急性肾损伤的新见解
DOI：
10.3389/fphar.2022.1065867
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发表时间：
2022
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
急性肾损伤（Acute kidney injury，阿基）是世界范围内发病率最高的临床疾病之一，其特点是肾功能迅速恶化，并进一步引发代谢废物和毒素的积累，导致其他器官的并发症和功能障碍。多种致病因素，如横纹肌溶解、感染、肾毒性药物和缺血再灌注损伤，有助于阿基的发生和进展。然而，详细的机制仍不清楚。铁凋亡，最近确定的非凋亡性细胞死亡的机制，是铁依赖性和脂质过氧化物在细胞中的积累引起的。各种研究已经证明，与其他形式的细胞死亡（如细胞凋亡、坏死性凋亡和焦亡）相比，铁凋亡在阿基发展中起重要作用。本文就阿基中铁凋亡的定义、主要生化机制、关键调控因子及相关药理学研究进展作一综述。我们进一步探讨了其预防阿基的治疗潜力，希望为进一步的基础和临床研究提供有益的参考。
Acute kidney injury (AKI), one of the most prevalent clinical diseases with a high incidence rate worldwide, is characterized by a rapid deterioration of renal function and further triggers the accumulation of metabolic waste and toxins, leading to complications and dysfunction of other organs. Multiple pathogenic factors, such as rhabdomyolysis, infection, nephrotoxic medications, and ischemia-reperfusion injury, contribute to the onset and progression of AKI. However, the detailed mechanism remains unclear. Ferroptosis, a recently identified mechanism of nonapoptotic cell death, is iron-dependent and caused by lipid peroxide accumulation in cells. A variety of studies have demonstrated that ferroptosis plays a significant role in AKI development, in contrast to other forms of cell death, such as apoptosis, necroptosis, and pyroptosis. In this review, we systemically summarized the definition, primary biochemical mechanisms, key regulators and associated pharmacological research progress of ferroptosis in AKI. We further discussed its therapeutic potential for the prevention of AKI, in the hope of providing a useful reference for further basic and clinical studies.
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影响因子：
5.5
作者：
Consoli V;Sorrenti V;Grosso S;Vanella L
通讯作者：
Vanella L
影响因子：
64.5
作者：
Dixon SJ;Lemberg KM;Lamprecht MR;Skouta R;Zaitsev EM;Gleason CE;Patel DN;Bauer AJ;Cantley AM;Yang WS;Morrison B 3rd;Stockwell BR
通讯作者：
Stockwell BR
影响因子：
4.9
作者：
Bao YW;Yuan Y;Chen JH;Lin WQ
通讯作者：
Lin WQ
影响因子：
24.1
作者：
Bertheloot D;Latz E;Franklin BS
通讯作者：
Franklin BS
DOI：
10.1164/rccm.200907-1047oc
发表时间：
2010-07-01
影响因子：
24.7
作者：
Cho, Hye-Youn;Gladwell, Wesley;Kleeberger, Steven R.
通讯作者：
Kleeberger, Steven R.