Alterations in platelet function during aging: clinical correlations with thromboinflammatory disease in older adults.
Alterations in platelet function during aging: clinical correlations with thromboinflammatory disease in older adults.
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DOI：
10.1111/jgs.12700
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发表时间：
2014-03
影响因子：
6.3
通讯作者：
Rondina MT
中科院分区：
文献类型：
--
作者：
Mohebali D;Kaplan D;Carlisle M;Supiano MA;Rondina MT
血小板具有调节止血和炎症反应的动态功能。在老年人中，这些功能中的许多都会改变，促进血栓形成和促炎环境，并增加不良临床事件的风险。这篇综述主要从人体研究中总结了与衰老相关的血小板变化的关键方面。在老年人中，血小板功能改变与血栓和炎症性疾病之间的关系被强调。根据这些数据，还讨论了已建立和正在开发的用于治疗血栓和炎症性疾病的抗血小板疗法。
Platelets possess a dynamic functional repertoire that mediates hemostatic and inflammatory responses. Many of these functions are altered in older adults, promoting a pro-thrombotic and pro-inflammatory milieu and contributing to an increased risk of adverse clinical events. This review summarizes, drawing primarily from human studies, key aspects of aging-related changes in platelets. The relationship between altered platelet functions and thrombotic and inflammatory disorders in older adults is highlighted. Established and developing anti-platelet therapies for the treatment of thrombotic and inflammatory disorders are also discussed in light of these data.
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