25-Hydroxyvitamin D deficiency is associated with fatal stroke among whites but not blacks: The NHANES-III linked mortality files.
25-Hydroxyvitamin D deficiency is associated with fatal stroke among whites but not blacks: The NHANES-III linked mortality files.
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DOI：
10.1016/j.nut.2011.10.015
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Melamed ML
中科院分区：
文献类型：
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作者：
Michos ED;Reis JP;Post WS;Lutsey PL;Gottesman RF;Mosley TH;Sharrett AR;Melamed ML
缺乏25-羟基维生素D [25(OH)D]水平与心血管疾病（CVD）事件和死亡率相关。25(OH)D缺乏症和中风在黑人中更为普遍。我们研究了与白人相比，低25(OH)D是否会导致黑人致命中风的风险增加。第三次全国健康和营养检查调查，对美国平民进行概率抽样，在1988-1994年间测量了25(OH)D水平和心血管疾病的危险因素。通过与国家死亡指数的联系，获得了截至2006年12月的重要状况。在基线时报告无心血管疾病的白人和黑人成年人中（n=7981），采用Cox回归模型估计25(OH)D状态和种族对致死性卒中的危险比（HR）。在平均14.1年的时间里，白人和黑人分别有116例和60例致命中风。在经社会经济地位和心血管疾病危险因素调整后的模型中，黑人发生致命性中风的风险高于白人[HR 1.60 (95% CI 1.01-2.53)]。黑人的平均基线25(OH)D水平明显低于白人（分别为19.4和30.8 ng/mL）。在多变量调整模型中，白人中缺乏25(OH)D水平<15 ng/mL与致命性中风相关[HR 2.13(1.01-4.50)]，而黑人则无关[HR 0.93(0.49-1.80)]。维生素D缺乏与白人中风死亡风险增加有关，但与黑人无关。虽然黑人比白人有更高的致命中风的几率，但黑人体内较低的25(OH)D水平与中风发病率无关，因此25(OH)D水平并不能解释这种额外的风险。
Deficient 25-hydroxyvitamin D [25(OH)D] levels are associated with cardiovascular disease (CVD) events and mortality. Both 25(OH)D deficiency and stroke are more prevalent among blacks. We examined whether low 25(OH)D contributes to the excess risk of fatal stroke in blacks compared to whites. The Third National Health and Nutrition Examination Survey, a probability sample of US civilians, measured 25(OH)D levels and CVD risk factors between 1988–1994. Vital status through December 2006 was obtained via linkage with the National Death Index. Among white and black adults without CVD reported at baseline (n=7981), Cox regression models were fit to estimate hazard ratios (HR) for fatal stroke by 25(OH)D status and race. During a median of 14.1 years, there were 116 and 60 fatal strokes among whites and blacks respectively. The risk of fatal stroke was greater in blacks compared to whites in models adjusted for socio-economic status and CVD risk factors, [HR 1.60 (95% CI 1.01–2.53)]. Mean baseline 25(OH)D levels were significantly lower in blacks compared to whites (19.4 vs 30.8 ng/mL, respectively). In multivariable-adjusted models, deficient 25(OH)D levels <15 ng/mL were associated with fatal stroke among whites [HR 2.13 (1.01–4.50)] but not blacks [HR 0.93 (0.49–1.80)]. Vitamin D deficiency was associated with increased risk of stroke death in whites but not blacks. Although blacks had a higher rate of fatal stroke compared to whites, the low 25(OH)D levels in blacks were unrelated to stroke incidence and therefore 25(OH)D levels did not explain this excess risk.
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影响因子：
4
作者：
Gutierrez, O. M.;Farwell, W. R.;Kermah, D.;Taylor, E. N.
通讯作者：
Taylor, E. N.
影响因子：
5.4
作者：
Knekt, Paul;Laaksonen, Maarit;Reunanen, Antti
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影响因子：
8.3
作者：
Rosamond, WD;Folsom, AR;Shahar, E
通讯作者：
Shahar, E
影响因子：
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作者：
Reis, Jared P.;Michos, Erin D.;Miller, Edgar R., III
通讯作者：
Miller, Edgar R., III
影响因子：
--
作者：
Melamed, Michal L.;Michos, Erin D.;Post, Wendy;Astor, Brad
通讯作者：
Astor, Brad