Great expectorations: the potential of salivary 'omic' approaches in neonatal intensive care.
Great expectorations: the potential of salivary 'omic' approaches in neonatal intensive care.
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DOI：
10.1038/jp.2013.170
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发表时间：
2014-03
影响因子：
2.9
通讯作者：
Maron, J. L.
中科院分区：
文献类型：
--
作者：
Romano-Keeler, J.;Wynn, J. L.;Maron, J. L.
在那些需要重症监护的早产儿中，早产儿对临床或基于研究的评估的可用血液或体液的限制最大。最近的技术进步提高了我们在纳米级水平上检测遗传、蛋白质组和微生物材料的能力，使分析物和生物标志物评估即使是最小的数量也成为可能。唾液是一种独特的体液，不仅可以无创和重复获得，而且还含有多种血清成分，使其有希望用于新生儿的无创评估。新生儿唾液的高通量或“组学”方法的整合具有很大的潜力，以提高诊断和预后的准确性，为广泛的发展和病理条件影响脆弱的早产儿群体。在此，我们回顾了唾液“组学”技术整合到新生儿重症监护病房（NICU）的临床应用和技术考虑。
Among those that require critical care, preterm neonates have the greatest limitations on available blood or body fluids for clinical or research-based assessments. Recent technological advancements have improved our ability to detect genetic, proteomic and microbial material at the nanoscale level, making analyte and biomarker assessment from even the smallest quantities possible. Saliva is a unique body fluid that not only may be noninvasively and repeatedly obtained, but also contains multiple serum components making it promising for noninvasive assessment of the newborn. The integration of high-throughput or ‘omic’ approaches on neonatal saliva holds great potential to improve diagnostic and prognostic accuracy for a wide range of developmental and pathological conditions affecting the vulnerable preterm neonatal population. Herein, we review the clinical applications and technical considerations regarding the integration of salivary ‘omic’ technology into the neonatal intensive care unit (NICU).
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影响因子：
2.1
作者：
Benitz, William E.
通讯作者：
Benitz, William E.
DOI：
10.1073/pnas.1002601107
发表时间：
2010-06-29
影响因子：
11.1
作者：
Dominguez-Bello, Maria G.;Costello, Elizabeth K.;Knight, Rob
通讯作者：
Knight, Rob
影响因子：
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作者：
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通讯作者：
Brogan, Thomas V.
影响因子：
3
作者：
Campese, Melanie;Sun, Xiuli;Bosch, Jos A.;Oppenheim, Frank G.;Helmerhorst, Eva J.
通讯作者：
Helmerhorst, Eva J.
影响因子：
3.7
作者：
Gallo A;Tandon M;Alevizos I;Illei GG
通讯作者：
Illei GG