Capillary blood flow imaging within human finger cuticle using optical microangiography.

Capillary blood flow imaging within human finger cuticle using optical microangiography.
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DOI:
10.1002/jbio.201300154
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发表时间:
2015-01
影响因子:
2.8
通讯作者:
Wang, Ruikang K.
Wang, Ruikang K.
中科院分区:
物理与天体物理2区
文献类型:
--
作者:
Baran, Utku;Shi, Lei;Wang, Ruikang K.

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我们报告了使用多普勒光学微血管造影(DOMAG)和超高灵敏度光学微血管造影(UHS-OMAG)技术对人手指表皮内毛细血管血流进行无创三维成像。应用宽速度范围DOMAG方法提供毛细血管袢中红细胞轴向速度图,范围为±0.9 mm/s和±0.3 mm/s。此外,UHS-OMAG技术被设计用于获得毛细血管形态的高分辨率图像。所呈现的结果有望通过量化人类手指角质层内的皮肤血流变化来促进糖尿病、雷诺现象和结缔组织疾病等各种疾病的治疗和诊断的临床试验。人手指表皮毛细血管双向红细胞轴向速度图的最大投影图像。
We report non-invasive 3D imaging of capillary blood flow within human finger cuticle by the use of Doppler optical microangiography (DOMAG) and ultra-high sensitive optical microangiography (UHS-OMAG) techniques. Wide velocity range DOMAG method is applied to provide RBC axial velocity mapping in capillary loops with ranges of ±0.9 mm/s and ±0.3 mm/s. Additionally, UHS-OMAG technique is engineered to acquire high resolution image of capillary morphology. The presented results are promising to facilitate clinical trials of treatment and diagnosis of various diseases such as diabetes, Raynaud's phenomenon, and connective tissue diseases by quantifying cutaneous blood flow changes within human finger cuticle. Maximum projection image of the bidirectional RBC axial velocity mapping in the human finger cuticle capillaries.
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