Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management.
Emerging Role of Hydrogels in Drug Delivery Systems, Tissue Engineering and Wound Management.
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DOI：
10.3390/pharmaceutics13030357
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发表时间：
2021-03-08
期刊：
影响因子：
5.4
通讯作者：
Shinu P
中科院分区：
文献类型：
--
作者：
Jacob S;Nair AB;Shah J;Sreeharsha N;Gupta S;Shinu P
水凝胶作为生物材料受欢迎的原因在于其可调的物理性质、包封小分子和大分子药物的能力、持水能力、柔韧性和可控性。本文综述了功能化策略，以克服传统水凝胶的不足，扩大先进的水凝胶如DNA水凝胶的作用。不同类型的交联技术，所使用的材料，程序，优点和缺点涵盖水凝胶的表格。描述了水凝胶的应用，特别是在口腔、口腔、阴道和透皮给药系统中的应用。综述还重点介绍了正在开发的具有增强性能的复合水凝胶，以满足伤口敷料的多样化需求。解释了水凝胶纳米颗粒在靶向和细胞内递送各种治疗剂方面的独特优势。此外，还讨论了用于组织工程应用和隐形眼镜制造的不同类型的水凝胶基材料。本文还提供了精选的商业产品示例的概述，特别是在口服和眼部药物输送系统和伤口敷料领域。水凝胶的制备具有多种特性，可实现生物稳定、生物可吸收和生物可降解的聚合物基质，其机械性能和膨胀程度可根据特定应用进行定制。这些独特的特性使其在给药系统和应用生物医学领域具有广阔的发展前景。
The popularity of hydrogels as biomaterials lies in their tunable physical properties, ability to encapsulate small molecules and macromolecular drugs, water holding capacity, flexibility, and controllable degradability. Functionalization strategies to overcome the deficiencies of conventional hydrogels and expand the role of advanced hydrogels such as DNA hydrogels are extensively discussed in this review. Different types of cross-linking techniques, materials utilized, procedures, advantages, and disadvantages covering hydrogels are tabulated. The application of hydrogels, particularly in buccal, oral, vaginal, and transdermal drug delivery systems, are described. The review also focuses on composite hydrogels with enhanced properties that are being developed to meet the diverse demand of wound dressing materials. The unique advantages of hydrogel nanoparticles in targeted and intracellular delivery of various therapeutic agents are explained. Furthermore, different types of hydrogel-based materials utilized for tissue engineering applications and fabrication of contact lens are discussed. The article also provides an overview of selected examples of commercial products launched particularly in the area of oral and ocular drug delivery systems and wound dressing materials. Hydrogels can be prepared with a wide variety of properties, achieving biostable, bioresorbable, and biodegradable polymer matrices, whose mechanical properties and degree of swelling are tailored with a specific application. These unique features give them a promising future in the fields of drug delivery systems and applied biomedicine.
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