Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trial.
Increasing overall physical activity and aerobic fitness is associated with improvements in metabolic risk: cohort analysis of the ProActive trial.
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DOI：
10.1007/s00125-008-0949-4
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发表时间：
2008-05
期刊：
影响因子：
8.2
通讯作者：
Ekelund, U.
中科院分区：
文献类型：
--
作者：
Simmons, R. K.;Griffin, S. J.;Steele, R.;Wareham, N. J.;Ekelund, U.
我们的目的是在有糖尿病家族史的个体中，研究一年来体力活动能量消耗(PAEE)、全身运动(每天的次数)和有氧健身(最大耗氧量[])的变化与代谢风险之间的关系。在前瞻性试验中，365名2型糖尿病患者的后代接受了能量消耗(使用FLEX心率方法测量的PAEE)、总的身体活动量(来自加速计数据的每日活动计数)、从次最大跑步机运动试验预测的总运动量以及基线和1年时的人体测量和代谢状况(n = 321)的测量。通过将腰围、空腹三酰甘油、胰岛素和血糖、血压和高密度脂蛋白-胆固醇的标准化值相加来计算聚集的代谢风险。采用线性回归的方法来量化PAEE的变化、整体身体活动和健康状况以及在随访时聚集的代谢风险之间的关系。参与者的活动量比一年前增加了0.01U Pee kJ kg−1天−1。身体总活动量平均每天增加9848次。整体身体运动(β = −0.066，p = 0.004)和健康(β = −0.056，p = 0.003)的变化与随访时的聚集性代谢风险相关，与年龄、性别、吸烟状况、社会经济状况和基线代谢评分无关。在这群经过仔细研究的高危人群中，活动量和体能的小幅增加与聚集性代谢风险的降低有关。进一步的研究，量化与这些变量的可行变化相关的2型糖尿病风险的降低，应为预防干预提供信息。临床试验注册号：ISRCTN61323766。
Our aim was to examine the association between change in physical activity energy expenditure (PAEE), total body movement (counts per day) and aerobic fitness (maximum oxygen consumption []) over 1 year and metabolic risk among individuals with a family history of diabetes. Three hundred and sixty-five offspring of people with type 2 diabetes underwent measurement of energy expenditure (PAEE measured using the flex heart rate method), total body movement (daily activity counts from accelerometry data), predicted from a submaximal graded treadmill exercise test and anthropometric and metabolic status at baseline and 1 year (n = 321) in the ProActive trial. Clustered metabolic risk was calculated by summing standardised values for waist circumference, fasting triacylglycerol, insulin and glucose, blood pressure and the inverse of HDL-cholesterol. Linear regression was used to quantify the association between changes in PAEE, total body movement and fitness and clustered metabolic risk at follow-up. Participants increased their activity by 0.01 units PAEE kJ kg−1 day−1 over 1 year. Total body movement increased by an average of 9,848 counts per day. Change in total body movement (β = −0.066, p = 0.004) and fitness (β = −0.056, p = 0.003) was associated with clustered metabolic risk at follow-up, independently of age, sex, smoking status, socioeconomic status and baseline metabolic score. Small increases in activity and fitness were associated with a reduction in clustered metabolic risk in this cohort of carefully characterised at-risk individuals. Further research to quantify the reduction in risk of type 2 diabetes associated with feasible changes in these variables should inform preventive interventions. Clinical trial registration number: ISRCTN61323766.
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影响因子：
4.5
作者：
Williams K;Prevost AT;Griffin S;Hardeman W;Hollingworth W;Spiegelhalter D;Sutton S;Ekelund U;Wareham N;Kinmonth AL
通讯作者：
Kinmonth AL
影响因子：
16.2
作者：
Ford, ES
通讯作者：
Ford, ES
DOI：
10.1249/01.mss.0000176466.78408.cc
发表时间：
2005-10-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
Corder, K;Brage, S;Ekelund, U
通讯作者：
Ekelund, U
影响因子：
16.2
作者：
Ekelund, Ulf;Griffin, Simon J.;Wareham, Nicholas J.
通讯作者：
Wareham, Nicholas J.
影响因子：
16.2
作者：
Ekelund, U;Brage, S;Wareham, NJ
通讯作者：
Wareham, NJ