Insulin resistance is an independent determinate of ED in young adult men.
Insulin resistance is an independent determinate of ED in young adult men.
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胰岛素抵抗是年轻男性 ED 的独立决定因素
DOI：
10.1371/journal.pone.0083951
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Deng C
中科院分区：
文献类型：
--
作者：
Chen S;Wu R;Huang Y;Zheng F;Ou Y;Tu X;Zhang Y;Gao Y;Chen X;Zheng T;Yang Q;Wan Z;Zhang Y;Sun X;Liu G;Deng C
背景胰岛素抵抗（IR）可引起内皮功能障碍，进而导致勃起功能障碍（艾德）和心血管疾病。目的探讨IR与艾德性ED的关系。方法283名连续主诉艾德至少6个月的男性被纳入研究，收集完整的病史、体格检查和实验室检查。采用QUICKI法测定IR，采用IIEF-5量表评估艾德的严重程度。通过超声检查肱动脉血流介导的舒张功能（FMD）来评估内皮功能。结果52%的患者存在胰岛素抵抗。IR受试者的总胆固醇、甘油三酯、低密度脂蛋白胆固醇（LDL-c）、糖化血红蛋白（HBA 1c）、高敏C反应蛋白（hs-CRP）和体重指数（BMI）显著升高，但IIEF-5评分、FMD%、高密度脂蛋白胆固醇（HDL-c）、睾酮、多元回归分析显示QUICKI和睾酮是IIEF-5评分的独立预测因子。此外，IR的发生率与ED的严重程度相关。结论与其他CVF相比，IR在我们的研究对象中是最常见的。此外，IR与艾德及其严重程度独立相关，提示胰岛素抵抗对勃起功能的不利影响。
Background Insulin resistance (IR) triggers endothelial dysfunction, which contributes to erectile dysfunction (ED) and cardiovascular disease. Aim To evaluate whether IR was related to ED in young adult patients. Methods A total of 283 consecutive men complaining of ED at least six months were enrolled, with a full medical history, physical examination, and laboratory tests collected. Quantitative Insulin Sensitivity Check Index (QUICKI) was used to determine IR. The severity of ED was assessed by IIEF-5 questionnaire. Endothelial function was assessed by ultrasonographic examination of brachial artery flow mediated dilation (FMD). Results IR was detected in 52% patients. Subjects with IR had significant higher total cholesterol, triglycerides, low density lipoprotein-cholesterol (LDL-c), glycated haemoglobin (HBA1c), high sensitivity C-reactive protein (hs-CRP) and body mass index (BMI), but showed significant lower IIEF-5 score, FMD%, high density lipoprotein -cholesterol (HDL-c), testosterone, sex hormone binding globulin (SHBG) levels than patients without IR. Multiple regression analysis showed QUICKI and testosterone were independent predictors of IIEF-5 score. Furthermore, the incidence of IR was correlated with the severity of ED. Conclusions Compared with other CVFs, IR was found as the most prevalent in our subjects. Besides, IR was independently associated with ED and its severity, suggesting an adverse effect of insulin resistance on erectile function.
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影响因子：
8.9
作者：
Inman BA;Sauver JL;Jacobson DJ;McGree ME;Nehra A;Lieber MM;Roger VL;Jacobsen SJ
通讯作者：
Jacobsen SJ
影响因子：
2.6
作者：
Demir, Tevfik
通讯作者：
Demir, Tevfik
影响因子：
9.3
作者：
An, Xuanqi;Yu, Dong;Xiong, Xiaowei
通讯作者：
Xiong, Xiaowei
影响因子：
4
作者：
Goglia, L.;Tosi, V.;Simoncini, T.
通讯作者：
Simoncini, T.
影响因子：
3.5
作者：
Martins, Fernando Gonini;Najjar Abdo, Carmita Helena
通讯作者：
Najjar Abdo, Carmita Helena