Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls.
Color-selective photophobia in ictal vs interictal migraineurs and in healthy controls.
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DOI：
10.1097/j.pain.0000000000001303
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发表时间：
2018-10
期刊：
影响因子：
7.4
通讯作者：
Burstein R
中科院分区：
文献类型：
--
作者：
Nir RR;Lee AJ;Huntington S;Noseda R;Bernstein CA;Fulton AB;Bertisch SM;Hovaguimian A;Buettner C;Borsook D;Burstein R
对光线的厌恶在偏头痛急性发作时很常见。通过对发作性偏头痛患者的心理物理评估，我们报告了与绿光相比，白色、蓝色、琥珀色和红色的灯在更大程度上加重了偏头痛患者的比例。这项研究的目的是确定这些发现是阶段依赖性的——即，只在偏头痛期间表现出来（急性发作），而不是在没有偏头痛时表现出来（间歇发作），还是条件依赖性的——即，只在偏头痛患者中表现出来，而在健康对照中没有。为了确定偏头痛型畏光的颜色偏好是依赖于相位还是依赖于条件，我们比较了偏头痛发作期间和发作之间与健康对照之间每种光的颜色和强度的影响。在发作期和发作间期，偏头痛患者在暴露于不同颜色的光时报告头痛严重程度发生变化的比例随着光强度的增加而增加。在发作期，白色、蓝色、琥珀色和红色灯光加重了约80%的患者的头痛；然而，在间歇期，光引发头痛的只有16-19%。值得注意的是，在发作期和发作间期，绿灯分别加重了40%的患者的头痛，并引发了3%的患者的头痛。除了一个例外（最高红光强度），没有对照受试者报告对光刺激有头痛反应。这些发现表明，颜色偏好是偏头痛患者独有的——因为在对照组中没有发现——并且与患者是否处于发作期或发作期无关。
Aversion to light is common among migraineurs undergoing acute attacks. Using psychophysical assessments in episodic migraine patients, we reported that white, blue, amber and red lights exacerbate migraine headache in a significantly larger percentage of patients and to a greater extent compared to green light. This study aimed at determining whether these findings are phase-dependent – namely, manifested exclusively during migraine (ictally) but not in its absence (interictally), or condition-dependent - i.e., expressed uniquely in migraineurs but not in healthy controls. To determine whether the color-preference of migraine-type photophobia is phase- or condition-dependent, we compared the effects of each color of light in each intensity between migraineurs during and in-between attacks and healthy controls. During the ictal and interictal phases, the proportion of migraineurs reporting changes in headache severity when exposed to the different colors of light increased in accordance with elevated light intensities. During the ictal phase, white, blue, amber and red lights exacerbated headaches in ~80% of the patients; however, during the interictal phase light initiated headache in only 16–19%. Notably, green light exacerbated headaches in 40% and triggered headaches in 3% of the patients studied during the ictal and interictal phases, respectively. With one exception (highest red light intensity), no control subject reported headache in response to the light stimuli. These findings suggest that color preference is unique to migraineurs - as it was not found in control subjects - and that it is independent of whether or not the patients are in their ictal or interictal phase.
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影响因子：
1.7
作者：
Conlon, E;Lovegrove, W;Hayes-Williams, K
通讯作者：
Hayes-Williams, K
DOI：
10.1177/0333102412474503
发表时间：
2013-04
期刊：
Cephalalgia : an international journal of headache
影响因子：
--
作者：
Datta R;Aguirre GK;Hu S;Detre JA;Cucchiara B
通讯作者：
Cucchiara B
影响因子：
4.9
作者：
Cucchiara, Brett;Datta, Ritobrato;Detre, John
通讯作者：
Detre, John
影响因子：
7.8
作者：
Hoyer, PO;Hyvärinen, A
通讯作者：
Hyvärinen, A
影响因子：
14.5
作者：
Afra, J;Cecchini, AP;Schoenen, J
通讯作者：
Schoenen, J