Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura.
Interictal cortical hyperresponsiveness in migraine is directly related to the presence of aura.
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DOI：
10.1177/0333102412474503
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发表时间：
2013-04
期刊：
影响因子：
--
通讯作者：
Cucchiara B
中科院分区：
文献类型：
--
作者：
Datta R;Aguirre GK;Hu S;Detre JA;Cucchiara B
本研究的目的是比较有先兆偏头痛（MWA），无先兆偏头痛（MwoA）和对照组之间的发作间期皮层反应的视觉刺激。在一项前瞻性病例对照研究中，血氧水平依赖性功能磁共振成像（BOLD fMRI）被用来评估对视觉刺激的反应，动脉自旋标记灌注MR被用来确定静息脑血流量。采用标准化问卷调查评估发作间期视觉不适。研究了75例受试者（25例MWA、25例MwoA和25例对照）。与MwoA（2.36± 0.13%，p=0.0008）和对照受试者（2.47± 0.11%，p= 0.002）相比，MWA（3.09±0.15%）对初级视皮层内视觉刺激的BOLD fMRI反应更大; MWA中外侧膝状体核的反应也更大。MwoA组和对照组之间无差异。全脑分析表明，增加激活MWA仅限于枕极。区域静息脑血流量组间无差异。与对照组相比，MWA和MwoA受试者发作间期视觉不适水平显著更高（分别为p=0.008和p=0.005），但这与BOLD反应无关。尽管类似的发作间期症状的视觉不适，只有MWA科目有皮质高反应性的视觉刺激，这表明皮质高反应性和先兆本身之间的直接联系。
The objective of this study was to compare the interictal cortical response to a visual stimulus between migraine with aura (MWA), migraine without aura (MwoA), and control subjects. In a prospective case-control study, blood oxygen level-dependent functional magnetic resonance imaging (BOLD fMRI) was used to assess the response to a visual stimulus and arterial spin labeled perfusion MR to determine resting cerebral blood flow. A standardized questionnaire was used to assess interictal visual discomfort. Seventy-five subjects (25 MWA, 25 MwoA, and 25 controls) were studied. BOLD fMRI response to visual stimulation within primary visual cortex was greater in MWA (3.09±0.15%) compared to MwoA (2.36±0.13%, p=0.0008) and control subjects (2.47±0.11%, p=0.002); responses were also greater in the lateral geniculate nuclei in MWA. No difference was found between MwoA and control groups. Whole brain analysis showed that increased activation in MWA was confined to the occipital pole. Regional resting cerebral blood flow did not differ between groups. MWA and MwoA subjects had significantly greater levels of interictal visual discomfort compared to controls (p=0.008 and p=0.005, respectively), but this did not correlate with BOLD response. Despite similar interictal symptoms of visual discomfort, only MWA subjects have cortical hyperresponsiveness to visual stimulus, suggesting a direct connection between cortical hyperresponsiveness and aura itself.
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影响因子：
4.8
作者：
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发表时间：
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期刊：
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影响因子：
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