Cryo-electron tomography of bacterial viruses.
Cryo-electron tomography of bacterial viruses.
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DOI:
10.1016/j.virol.2012.08.022
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发表时间:
2013-01-05
期刊:
影响因子:
3.7
通讯作者:
Wright ER
中科院分区:
文献类型:
--
作者:
Guerrero-Ferreira RC;Wright ER
Bacteriophage particles contain both simple and complex macromolecular assemblages and machines that enable them to regulate the infection process under diverse environmental conditions with a broad range of bacterial hosts. Recent developments in cryo-electron tomography (cryo-ET) make it possible to observe the interactions of bacteriophages with their host cells under native-state conditions at unprecedented resolution and in three-dimensions. This review describes the application of cryo-ET to studies of bacteriophage attachment, genome ejection, assembly and egress. Current topics of investigation and future directions in the field are also discussed.
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