A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior
A Deep Mesencephalic Nucleus Circuit Regulates Licking Behavior
复制标题
深层中脑核回路调节舔行为
DOI：
10.1007/s12264-021-00817-2
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发表时间：
2022-01
影响因子：
5.6
通讯作者：
Xiaoming Li
中科院分区：
文献类型：
--
作者：
Di Zheng;Jiayu Fu;Mengyu Tang;Xiaodan Yu;Yi Zhu;Chenjie Shen;Chunyue Li;Shize Xie;Shan Lin;Minmin Luo;Xiaoming Li
舔舐行为对水分摄入很重要。中脑深部核（DpMe）与本能行为有关。然而，DpMe是否参与舔舐行为以及这种行为背后的精确神经回路仍然未知。在这里，我们发现DpMe的活性随着水的摄入而降低。抑制DpMe中泡状谷氨酸转运蛋白2阳性（VGLUT2+）神经元导致水摄入量增加。表达生长抑素（SST+）而不表达蛋白激酶C-δ (PKC-δ+)的中央杏仁核（CeA） gaba能神经元优先支配DpMe VGLUT2+神经元。在舔食行为开始时，CeA中向DpMe投射的SST+神经元被激活。激活这些CeA - SST+ gabaergy神经元，而不是PKC-δ+ gabaergy神经元，投射到DpMe，足以诱导舔食行为并促进水摄入。这些发现重新定义了DpMe的作用，并揭示了一种新的ceasst - dpmevglut2回路，该回路调节舔舐行为并促进水分摄入。
Licking behavior is important for water intake. The deep mesencephalic nucleus (DpMe) has been implicated in instinctive behaviors. However, whether the DpMe is involved in licking behavior and the precise neural circuit behind this behavior remains unknown. Here, we found that the activity of the DpMe decreased during water intake. Inhibition of vesicular glutamate transporter 2-positive (VGLUT2+) neurons in the DpMe resulted in increased water intake. Somatostatin-expressing (SST+), but not protein kinase C-δ-expressing (PKC-δ+), GABAergic neurons in the central amygdala (CeA) preferentially innervated DpMe VGLUT2+neurons. The SST+neurons in the CeA projecting to the DpMe were activated at the onset of licking behavior. Activation of these CeA SST+GABAergic neurons, but not PKC-δ+GABAergic neurons, projecting to the DpMe was sufficient to induce licking behavior and promote water intake. These findings redefine the roles of the DpMe and reveal a novel CeASST–DpMeVGLUT2circuit that regulates licking behavior and promotes water intake.
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影响因子：
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作者：
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作者：
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通讯作者：
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