Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse.
Whole-Brain Map of Long-Range Monosynaptic Inputs to Different Cell Types in the Amygdala of the Mouse.
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DOI：
10.1007/s12264-020-00545-z
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发表时间：
2020-11
影响因子：
5.6
通讯作者：
Li XM
中科院分区：
文献类型：
--
作者：
Fu JY;Yu XD;Zhu Y;Xie SZ;Tang MY;Yu B;Li XM
据报道，杏仁核与各种行为和情绪有关，与整个大脑相连。然而，不同细胞类型的远程输入尚未被定义。在这里，我们使用逆行跨突触狂犬病病毒来生成小鼠杏仁核中主要细胞类型的输入的全脑地图。我们鉴定了37个投射到表达囊泡谷氨酸转运体2的神经元的区域，78个投射到表达小白蛋白的神经元的区域，104个投射到表达蛋白激酶C-δ的神经元的区域，以及89个投射到表达生长抑素的神经元的区域。杏仁核接受来自同皮质和纹状体的大量投射。几个核团，如尾壳核和海马CA 1区，表现出对杏仁核中不同细胞类型的输入偏好。值得注意的是，我们确定了几个新的输入区域，包括无名质和齿状突。这些发现提供了解剖学证据，有助于理解杏仁核的精确连接和各种功能。本文的在线版本（10.1007/s12264-020-00545-z）包含补充材料，可供授权用户使用。
The amygdala, which is involved in various behaviors and emotions, is reported to connect with the whole brain. However, the long-range inputs of distinct cell types have not yet been defined. Here, we used a retrograde trans-synaptic rabies virus to generate a whole-brain map of inputs to the main cell types in the mouse amygdala. We identified 37 individual regions that projected to neurons expressing vesicular glutamate transporter 2, 78 regions to parvalbumin-expressing neurons, 104 regions to neurons expressing protein kinase C-δ, and 89 regions to somatostatin-expressing neurons. The amygdala received massive projections from the isocortex and striatum. Several nuclei, such as the caudate-putamen and the CA1 field of the hippocampus, exhibited input preferences to different cell types in the amygdala. Notably, we identified several novel input areas, including the substantia innominata and zona incerta. These findings provide anatomical evidence to help understand the precise connections and diverse functions of the amygdala. The online version of this article (10.1007/s12264-020-00545-z) contains supplementary material, which is available to authorized users.
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