Recent Evolutionary History of Tigers Highlights Contrasting Roles of Genetic Drift and Selection.
Recent Evolutionary History of Tigers Highlights Contrasting Roles of Genetic Drift and Selection.
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DOI：
10.1093/molbev/msab032
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发表时间：
2021-05-19
影响因子：
10.7
通讯作者：
Ramakrishnan U
中科院分区：
文献类型：
--
作者：
Armstrong EE;Khan A;Taylor RW;Gouy A;Greenbaum G;Thiéry A;Kang JT;Redondo SA;Prost S;Barsh G;Kaelin C;Phalke S;Chugani A;Gilbert M;Miquelle D;Zachariah A;Borthakur U;Reddy A;Louis E;Ryder OA;Jhala YV;Petrov D;Excoffier L;Hadly E;Ramakrishnan U
物种保护可以通过进化和遗传历史的知识来改善。老虎是最具魅力的濒危物种之一，受到了广泛的保护关注。然而，它们的进化历史和基因组变异仍然知之甚少，尤其是印度虎。世界上 70% 的野生老虎生活在印度，这些知识至关重要。我们对代表大多数现存亚种的 65 只老虎个体基因组进行了重新测序，特别关注来自印度的老虎。正如早期研究表明的那样，我们发现假定的老虎亚种之间存在很强的遗传分化。尽管印度的总基因组多样性很高，但个别老虎拥有较长的纯合性，这可能表明最近发生了近亲繁殖或创始事件，这可能是由于保护区较小且分散。 We suggest the impacts of ongoing connectivity loss on inbreeding and persistence of Indian tigers be closely monitored.令人惊讶的是，人口统计模型表明最近亚种之间存在分歧（在过去 20,000 年之内），并且存在严重的人口瓶颈。东北虎基因组揭示了与寒冷代谢适应相关的最强选择信号，而苏门答腊虎则显示出与体型调节相关的基因选择较弱的证据。我们建议在开始基因拯救之前对阿穆尔虎和苏门答腊虎的局部适应进行详细调查。
Species conservation can be improved by knowledge of evolutionary and genetic history. Tigers are among the most charismatic of endangered species and garner significant conservation attention. However, their evolutionary history and genomic variation remain poorly known, especially for Indian tigers. With 70% of the world’s wild tigers living in India, such knowledge is critical. We re-sequenced 65 individual tiger genomes representing most extant subspecies with a specific focus on tigers from India. As suggested by earlier studies, we found strong genetic differentiation between the putative tiger subspecies. Despite high total genomic diversity in India, individual tigers host longer runs of homozygosity, potentially suggesting recent inbreeding or founding events, possibly due to small and fragmented protected areas. We suggest the impacts of ongoing connectivity loss on inbreeding and persistence of Indian tigers be closely monitored. Surprisingly, demographic models suggest recent divergence (within the last 20,000 years) between subspecies and strong population bottlenecks. Amur tiger genomes revealed the strongest signals of selection related to metabolic adaptation to cold, whereas Sumatran tigers show evidence of weak selection for genes involved in body size regulation. We recommend detailed investigation of local adaptation in Amur and Sumatran tigers prior to initiating genetic rescue.
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影响因子：
13.6
作者：
Hu, Yibo;Thapa, Arjun;Wei, Fuwen
通讯作者：
Wei, Fuwen
影响因子：
9.2
作者：
Chang CC;Chow CC;Tellier LC;Vattikuti S;Purcell SM;Lee JJ
通讯作者：
Lee JJ
在高度濒临灭绝的伊比利亚山脉中，经常性人口瓶颈后的极端基因组侵蚀。
影响因子：
12.3
作者：
Abascal F;Corvelo A;Cruz F;Villanueva-Cañas JL;Vlasova A;Marcet-Houben M;Martínez-Cruz B;Cheng JY;Prieto P;Quesada V;Quilez J;Li G;García F;Rubio-Camarillo M;Frias L;Ribeca P;Capella-Gutiérrez S;Rodríguez JM;Câmara F;Lowy E;Cozzuto L;Erb I;Tress ML;Rodriguez-Ales JL;Ruiz-Orera J;Reverter F;Casas-Marce M;Soriano L;Arango JR;Derdak S;Galán B;Blanc J;Gut M;Lorente-Galdos B;Andrés-Nieto M;López-Otín C;Valencia A;Gut I;García JL;Guigó R;Murphy WJ;Ruiz-Herrera A;Marques-Bonet T;Roma G;Notredame C;Mailund T;Albà MM;Gabaldón T;Alioto T;Godoy JA
通讯作者：
Godoy JA
影响因子：
3.7
作者：
Joshi A;Vaidyanathan S;Mondol S;Edgaonkar A;Ramakrishnan U
通讯作者：
Ramakrishnan U
影响因子：
16.6
作者：
Epstein, Brendan;Jones, Menna;Hamede, Rodrigo;Hendricks, Sarah;McCallum, Hamish;Murchison, Elizabeth P.;Schonfeld, Barbara;Wiench, Cody;Hohenlohe, Paul;Storfer, Andrew
通讯作者：
Storfer, Andrew