An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution.
An Ancestral Major Histocompatibility Complex Organization in Cartilaginous Fish: Reconstructing MHC Origin and Evolution.
复制标题
DOI：
10.1093/molbev/msad262
复制
发表时间：
2023-12-01
影响因子：
10.7
通讯作者：
Ohta, Yuko
中科院分区：
文献类型：
--
作者：
Verissimo, Ana;Castro, L. Filipe C.;Munoz-Merida, Antonio;Almeida, Tereza;Gaigher, Arnaud;Neves, Fabiana;Flajnik, Martin F.;Ohta, Yuko
软骨鱼（鲨鱼、鳐和嵌合体）是现存最古老的有颌脊椎动物，具有基于免疫球蛋白（IG）、T细胞受体（TCR）和主要组织相容性复合体（MHC）的类马克隆适应性免疫系统。在这里，我们表明，软骨鱼的“适应性MHC”是高度管制和紧凑，包含（i）一个经典的MHC Ia类（MHC-Ia）的抗原加工区，（ii）MHC II类（MHC-II）区，（具有α和β基因）与β-2-微球蛋白（β 2 m）和含溴结构域2连锁，（iii）具有4.5亿年历史谱系的非经典MHC Ib类（MHC-Ib）区域，和（iv）与MHC-Ia区相关的补体C4。在板鳃类MHC外没有发现MHC-Ib基因。我们的数据表明，MHC-I和MHC-II基因都是在人类染色体（huchr）6前体上的第二轮全基因组复制（2 R）后出现的。对所有有颌脊椎动物谱系的早期分支分类群的MHC旁系同源区域的进一步分析显示，IG/TCR基因可能出现在huchr 9/12/14 MHC旁系同源序列的前体上。在某些脊椎动物中，β 2 m基因与IG/TCR基因连锁，提示β 2 m基因存在于1 R位点，可能是原始MHC基因C1结构域的供体。总之，现存的软骨鱼表现出保守的和典型的MHC基因组组织中发现的各种脊椎动物的功能，反映了祖先的安排有颌脊椎动物。
Cartilaginous fish (sharks, rays, and chimeras) comprise the oldest living jawed vertebrates with a mammalian-like adaptive immune system based on immunoglobulins (Ig), T-cell receptors (TCRs), and the major histocompatibility complex (MHC). Here, we show that the cartilaginous fish “adaptive MHC” is highly regimented and compact, containing (i) a classical MHC class Ia (MHC-Ia) region containing antigen processing (antigen peptide transporters and immunoproteasome) and presenting (MHC-Ia) genes, (ii) an MHC class II (MHC-II) region (with alpha and beta genes) with linkage to beta-2-microglobulin (β2m) and bromodomain-containing 2, (iii) nonclassical MHC class Ib (MHC-Ib) regions with 450 million-year-old lineages, and (iv) a complement C4 associated with the MHC-Ia region. No MHC-Ib genes were found outside of the elasmobranch MHC. Our data suggest that both MHC-I and MHC-II genes arose after the second round of whole-genome duplication (2R) on a human chromosome (huchr) 6 precursor. Further analysis of MHC paralogous regions across early branching taxa from all jawed vertebrate lineages revealed that Ig/TCR genes likely arose on a precursor of the huchr9/12/14 MHC paralog. The β2m gene is linked to the Ig/TCR genes in some vertebrates suggesting that it was present at 1R, perhaps as the donor of C1 domain to the primordial MHC gene. In sum, extant cartilaginous fish exhibit a conserved and prototypical MHC genomic organization with features found in various vertebrates, reflecting the ancestral arrangement for the jawed vertebrates.
登录
查看更多内容
影响因子：
3.6
作者：
Almeida T;Gaigher A;Muñoz-Mérida A;Neves F;Castro LFC;Flajnik MF;Ohta Y;Esteves PJ;Veríssimo A
通讯作者：
Veríssimo A
影响因子：
4.4
作者：
Katsanis, N;Fitzgibbon, J;Fisher, EMC
通讯作者：
Fisher, EMC
DOI：
10.1038/nrg2703
发表时间：
2010-01
期刊：
Nature reviews. Genetics
影响因子：
--
作者：
通讯作者：
--
影响因子：
3.2
作者：
Castro, LFC;Furlong, RF;Holland, PWH
通讯作者：
Holland, PWH
影响因子：
9.8
作者：
Belov K;Deakin JE;Papenfuss AT;Baker ML;Melman SD;Siddle HV;Gouin N;Goode DL;Sargeant TJ;Robinson MD;Wakefield MJ;Mahony S;Cross JG;Benos PV;Samollow PB;Speed TP;Graves JA;Miller RD
通讯作者：
Miller RD